Featured Research

from universities, journals, and other organizations

New Insights Into Formation Of The Centromere, A Key Cellular Structure In Powering And Controlling Chromosome Segregation

Date:
July 13, 2009
Source:
Instituto Gulbenkian de Ciencia
Summary:
Scientists have described the formation of the centromere, a key cellular structure in powering and controlling chromosome segregation and accurate cell division.

A cell seen through a microscope: the chromosomes (in blue) are attached to the microtubule tracks (in red) in the region of the centromere -- green spots mark the protein CENP-A on the centromere.
Credit: Lars Jansen (IGC)

Lars Jansen* has described the formation of the centromere, a key cellular structure in powering and controlling chromosome segregation and accurate cell division.

Related Articles


A new Nature Cell Biology paper, published in collaboration with a group at Stanford University School of Medicine, provides insights into the scaffold of proteins that ensures accurate segregation of chromosomes during cell division - a fundamental step to ensure that daughter cells have the same genetic information as their mother, with reduced risk of cancer.

When segregating, chromosomes attach and move along proteins tracks (the mitotic spindle), from the centre of the cell to the poles. The centromere is the area of the chromosome that directs this attachment by controlling the assembly of a scaffold of proteins (called the kinetochore), which tether the chromosome to the spindle, and power its movement along the protein track. The location of the centromere on the chromosome is marked by the presence of a protein, called CENP-A, but how this protein is recognised by the other components of the cell to orchestrate the assembly of the centromere was not understood - until now.

Using a newly developed assay, Lars and his colleagues were able to identify the protein that triggers the assembly of the centromere. It's called CENP-N. According to Mariana Silva, a PhD student in the lab, 'When we depleted CENP-N in cells, the centromere did not assemble correctly and chromosomes segregated abnormally, leading to situations similar to cancer'.

This study shows the applicability of this new assay and open doors to future studies into centromere assembly and structure.

*Lars Jansen moved from California to the Instituto Gulbenkian de Ciκncia (IGC), in Portugal, last year to head the Epigenetic Mechanisms group.

An EMBO installation grant, of 50,000 euro per year, for a maximum of five years has been awarded.


Story Source:

The above story is based on materials provided by Instituto Gulbenkian de Ciencia. Note: Materials may be edited for content and length.


Cite This Page:

Instituto Gulbenkian de Ciencia. "New Insights Into Formation Of The Centromere, A Key Cellular Structure In Powering And Controlling Chromosome Segregation." ScienceDaily. ScienceDaily, 13 July 2009. <www.sciencedaily.com/releases/2009/07/090701102902.htm>.
Instituto Gulbenkian de Ciencia. (2009, July 13). New Insights Into Formation Of The Centromere, A Key Cellular Structure In Powering And Controlling Chromosome Segregation. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2009/07/090701102902.htm
Instituto Gulbenkian de Ciencia. "New Insights Into Formation Of The Centromere, A Key Cellular Structure In Powering And Controlling Chromosome Segregation." ScienceDaily. www.sciencedaily.com/releases/2009/07/090701102902.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Aquaponics Turn Suburban Industrial Park Into Farmland: Hume

Aquaponics Turn Suburban Industrial Park Into Farmland: Hume

The Toronto Star (Jan. 27, 2015) — Ancient techniques of growing greens with fish and water are well ahead of Toronto bylaws. Video provided by The Toronto Star
Powered by NewsLook.com
How To: Mixed Green Salad Topped With Camembert Cheese

How To: Mixed Green Salad Topped With Camembert Cheese

Rumble (Jan. 26, 2015) — Learn how to make a mixed green salad topped with a pan-seared camembert cheese in only a minute! Music: Courtesy of Audio Network. Video provided by Rumble
Powered by NewsLook.com
Water Fleas Prepare for Space Voyage

Water Fleas Prepare for Space Voyage

Reuters - Innovations Video Online (Jan. 26, 2015) — Scientists are preparing a group of water fleas for a unique voyage into space. The aquatic crustaceans, known as Daphnia, can be used as a miniature model for biomedical research, and their reproductive and swimming behaviour will be tested for signs of stress while on board the International Space Station. Jim Drury went to meet the team. Video provided by Reuters
Powered by NewsLook.com
Husky Puppy Plays With Ferret

Husky Puppy Plays With Ferret

Rumble (Jan. 26, 2015) — It looks like this 2-month-old Husky puppy and the family ferret are going to be the best of friends. Look at how much fun they&apos;re having together! Credit to &apos;Vira&apos;. Video provided by Rumble
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins