Featured Research

from universities, journals, and other organizations

Of yeast and men: An evolutionary tale

Date:
May 7, 2012
Source:
Research Institute of Molecular Pathology
Summary:
Scientists have discovered and elucidated the function of conserved cell division proteins in yeast.

Dividing human cancer cell. The DNA (gray) is attached to the spindle apparatus (pseudocolored). This cell is in metaphase, the cell division stage where duplicated chromosomes are optimally positioned for subsequent distribution to either spindle pole.
Credit: IMP/Ladurner

The adult human body consists of trillions of cells. Cell proliferation is accomplished by means of cell division in which an existing cell serves as the exact blueprint for its progeny. This process follows the same basic principles in all higher organisms. First, the genetic information is precisely copied and subsequently equally distributed between the mother and daughter. The major task for the dividing cell is to drag two complete sets of chromosomes to the opposite sides of the nucleus, respectively.

A logistic challenge accomplished by the interplay of two factors: the spindle apparatus that acts as the molecular motor driving chromosome movements, and the kinetochore that constitutes the physical platform between the DNA and the mitotic spindle.

The attachment site formed by the kinetochore is an intricate protein network. While its components providing the direct contact point for the spindle are very well preserved from yeast to human, evolution of the DNA-binding proteins remained puzzling given that the underlying DNA template is highly variable.

Now, a novel study published in the June edition of Nature Cell Biology sheds light onto the cryptic molecular relationship between the yeast and human kinetochore. Principal investigator Stefan Westermann and his team tracked the missing evolutionary link and opened up new insights into the architecture and function of the key division organelle.

The correct shape pieces the puzzle together

"The clue was to take a close look at the protein sequence as well as specific sequence motifs that get an amino acid chain into its particular shape." says Stefan Westermann. "In this way, our bioinformatician Alexander Schleiffer was able to predict a number of novel DNA-binding kinetochore proteins and assigned them to the respective human homolog." Follow-up experiments strongly supported analogous function of the proteins. "Yeast is still an informative model organism and very easy to handle. Our current findings can now direct similar studies in more complex systems. There erroneous chromosome segregation is deleterious for the cell and a common cause of cancer" explains the scientist.

Pull chromosomes together

One of the novel proteins, termed Cnn1, turns out to be of special interest. It connects to the kinetochore molecule Ndc80 that is the major contact point for the spindle apparatus. "This particular interaction is not essential for the initial attachment of the spindle. It rather plays a supporting role that timely overlaps with maximal pulling forces acting on the chromosomes" says Stefan Westermann.


Story Source:

The above story is based on materials provided by Research Institute of Molecular Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alexander Schleiffer, Michael Maier, Gabriele Litos, Fabienne Lampert, Peter Hornung, Karl Mechtler, Stefan Westermann. CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nature Cell Biology, 2012; DOI: 10.1038/ncb2493

Cite This Page:

Research Institute of Molecular Pathology. "Of yeast and men: An evolutionary tale." ScienceDaily. ScienceDaily, 7 May 2012. <www.sciencedaily.com/releases/2012/05/120507101802.htm>.
Research Institute of Molecular Pathology. (2012, May 7). Of yeast and men: An evolutionary tale. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2012/05/120507101802.htm
Research Institute of Molecular Pathology. "Of yeast and men: An evolutionary tale." ScienceDaily. www.sciencedaily.com/releases/2012/05/120507101802.htm (accessed July 26, 2014).

Share This




More Plants & Animals News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How to Make Single Serving Smoothies: Howdini Hacks

How to Make Single Serving Smoothies: Howdini Hacks

Howdini (July 24, 2014) Smoothies are a great way to get in lots of healthy ingredients, plus they taste great! Howdini has a trick for making the perfect single-size smoothie that will save you time on cleanup too! All you need is a blender and a mason jar. Video provided by Howdini
Powered by NewsLook.com
Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Newsy (July 24, 2014) A new study claims a set of prehistoric T-Rex footprints supports the theory that the giant predators hunted in packs instead of alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins