Featured Research

from universities, journals, and other organizations

Of yeast and men: An evolutionary tale

Date:
May 7, 2012
Source:
Research Institute of Molecular Pathology
Summary:
Scientists have discovered and elucidated the function of conserved cell division proteins in yeast.

Dividing human cancer cell. The DNA (gray) is attached to the spindle apparatus (pseudocolored). This cell is in metaphase, the cell division stage where duplicated chromosomes are optimally positioned for subsequent distribution to either spindle pole.
Credit: IMP/Ladurner

The adult human body consists of trillions of cells. Cell proliferation is accomplished by means of cell division in which an existing cell serves as the exact blueprint for its progeny. This process follows the same basic principles in all higher organisms. First, the genetic information is precisely copied and subsequently equally distributed between the mother and daughter. The major task for the dividing cell is to drag two complete sets of chromosomes to the opposite sides of the nucleus, respectively.

A logistic challenge accomplished by the interplay of two factors: the spindle apparatus that acts as the molecular motor driving chromosome movements, and the kinetochore that constitutes the physical platform between the DNA and the mitotic spindle.

The attachment site formed by the kinetochore is an intricate protein network. While its components providing the direct contact point for the spindle are very well preserved from yeast to human, evolution of the DNA-binding proteins remained puzzling given that the underlying DNA template is highly variable.

Now, a novel study published in the June edition of Nature Cell Biology sheds light onto the cryptic molecular relationship between the yeast and human kinetochore. Principal investigator Stefan Westermann and his team tracked the missing evolutionary link and opened up new insights into the architecture and function of the key division organelle.

The correct shape pieces the puzzle together

"The clue was to take a close look at the protein sequence as well as specific sequence motifs that get an amino acid chain into its particular shape." says Stefan Westermann. "In this way, our bioinformatician Alexander Schleiffer was able to predict a number of novel DNA-binding kinetochore proteins and assigned them to the respective human homolog." Follow-up experiments strongly supported analogous function of the proteins. "Yeast is still an informative model organism and very easy to handle. Our current findings can now direct similar studies in more complex systems. There erroneous chromosome segregation is deleterious for the cell and a common cause of cancer" explains the scientist.

Pull chromosomes together

One of the novel proteins, termed Cnn1, turns out to be of special interest. It connects to the kinetochore molecule Ndc80 that is the major contact point for the spindle apparatus. "This particular interaction is not essential for the initial attachment of the spindle. It rather plays a supporting role that timely overlaps with maximal pulling forces acting on the chromosomes" says Stefan Westermann.


Story Source:

The above story is based on materials provided by Research Institute of Molecular Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alexander Schleiffer, Michael Maier, Gabriele Litos, Fabienne Lampert, Peter Hornung, Karl Mechtler, Stefan Westermann. CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nature Cell Biology, 2012; DOI: 10.1038/ncb2493

Cite This Page:

Research Institute of Molecular Pathology. "Of yeast and men: An evolutionary tale." ScienceDaily. ScienceDaily, 7 May 2012. <www.sciencedaily.com/releases/2012/05/120507101802.htm>.
Research Institute of Molecular Pathology. (2012, May 7). Of yeast and men: An evolutionary tale. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2012/05/120507101802.htm
Research Institute of Molecular Pathology. "Of yeast and men: An evolutionary tale." ScienceDaily. www.sciencedaily.com/releases/2012/05/120507101802.htm (accessed October 20, 2014).

Share This



More Plants & Animals News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-Fuel Impala

Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-Fuel Impala

3BL Media (Oct. 20, 2014) Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-fuel Impala Video provided by 3BL
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins