Featured Research

from universities, journals, and other organizations

Antitumour proteins identified in the latex of the plant Euphorbia trigona

Date:
June 21, 2012
Source:
Basque Research
Summary:
Scientists have identified, isolated and characterized anti-tumor proteins present in the latex of the plant Euphorbia Trigona.

Latex.
Credit: Image courtesy of Basque Research

The Basque Institute for Agricultural Research and Development Neiker-Tecnalia has identified, isolated and characterized anti-tumor proteins present in the latex of the plant Euphorbia Trigona. Scientists have demonstrated that the purified proteins can inhibit the growth of several tumor cell lines. This property shows that the latex proteins of this plant, which is very prolific and easily acclimated, could be considered in clinical trials for cancer treatment due to its anti-tumor activity.

The research has been done in collaboration with the University of Oviedo (Spain) and with funding from the Department for the Environment, Territorial Planning, Agriculture and Fisheries of the Government of the Basque Autonomous Community (region).

Latex comprises various substances including proteins that play a very active role in defending the plant, like proteases, chitinases, oxidases and lectins. These latter proteins constitute a very valuable tool for studying membrane structure and for detecting malignant transformations, among other types of research. Identifying plants which have proteins of interest in biomedicine is one of scientific objectives. In this aspect, Neiker-Tecnalia has selected Euphorbia trigona, a succulent plant of African origin and belonging to the euphorbiaceae family.

In the latex of Euphorbia trigona the scientists of the R+D Centre and the University of Oviedo found three proteins belonging to the RIP (Ribosome Inactivating Protein) family. The purified proteins by specialists were able to inhibit eukaryotic ribosomes in cell-free systems, and also showed cytotoxic activity -the ability to inhibit cell growth- when tested with different tumor cell lines.

In addition to the antitumour activity, the researchers observed a possible antifungal activity -the ability to fight infections caused by fungi- of the lectins present in the latex of this plant. This potential antifungal activity opens an interesting line of research in finding new uses for latex proteins of E. trigona against various diseases.

Lectins currently represent the most versatile group of plant proteins used in basic and applied biological and biomedical research. They offer a broad range of potential applications in biotechnology, mainly in three areas: research into bioactive proteins, plant cultures for improving the defense system against predators, and biomedicine for diagnosis and therapeutic treatment. In fact, a lectin extracted from mistletoe is the active substance, marketed as Iscador and Isorel, currently used in treating cancer. Lectins can also display anti-viral, antibacterial, anti-fungal and insecticide activity.


Story Source:

The above story is based on materials provided by Basque Research. Note: Materials may be edited for content and length.


Cite This Page:

Basque Research. "Antitumour proteins identified in the latex of the plant Euphorbia trigona." ScienceDaily. ScienceDaily, 21 June 2012. <www.sciencedaily.com/releases/2012/06/120621113333.htm>.
Basque Research. (2012, June 21). Antitumour proteins identified in the latex of the plant Euphorbia trigona. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2012/06/120621113333.htm
Basque Research. "Antitumour proteins identified in the latex of the plant Euphorbia trigona." ScienceDaily. www.sciencedaily.com/releases/2012/06/120621113333.htm (accessed July 29, 2014).

Share This




More Plants & Animals News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
Asteroid's Timing Was 'Colossal Bad Luck' For The Dinosaurs

Asteroid's Timing Was 'Colossal Bad Luck' For The Dinosaurs

Newsy (July 28, 2014) The asteroid that killed the dinosaurs struck at the worst time for them. A new study says that if it hit earlier or later, they might've survived. Video provided by Newsy
Powered by NewsLook.com
Raw: Sea Turtle Hatchlings Emerge from Nest

Raw: Sea Turtle Hatchlings Emerge from Nest

AP (July 27, 2014) A live-streaming webcam catches loggerhead sea turtle hatchlings emerging from a nest in the Florida Keys. (July 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins