Featured Research

from universities, journals, and other organizations

Antitumour proteins identified in the latex of the plant Euphorbia trigona

Date:
June 21, 2012
Source:
Basque Research
Summary:
Scientists have identified, isolated and characterized anti-tumor proteins present in the latex of the plant Euphorbia Trigona.

Latex.
Credit: Image courtesy of Basque Research

The Basque Institute for Agricultural Research and Development Neiker-Tecnalia has identified, isolated and characterized anti-tumor proteins present in the latex of the plant Euphorbia Trigona. Scientists have demonstrated that the purified proteins can inhibit the growth of several tumor cell lines. This property shows that the latex proteins of this plant, which is very prolific and easily acclimated, could be considered in clinical trials for cancer treatment due to its anti-tumor activity.

The research has been done in collaboration with the University of Oviedo (Spain) and with funding from the Department for the Environment, Territorial Planning, Agriculture and Fisheries of the Government of the Basque Autonomous Community (region).

Latex comprises various substances including proteins that play a very active role in defending the plant, like proteases, chitinases, oxidases and lectins. These latter proteins constitute a very valuable tool for studying membrane structure and for detecting malignant transformations, among other types of research. Identifying plants which have proteins of interest in biomedicine is one of scientific objectives. In this aspect, Neiker-Tecnalia has selected Euphorbia trigona, a succulent plant of African origin and belonging to the euphorbiaceae family.

In the latex of Euphorbia trigona the scientists of the R+D Centre and the University of Oviedo found three proteins belonging to the RIP (Ribosome Inactivating Protein) family. The purified proteins by specialists were able to inhibit eukaryotic ribosomes in cell-free systems, and also showed cytotoxic activity -the ability to inhibit cell growth- when tested with different tumor cell lines.

In addition to the antitumour activity, the researchers observed a possible antifungal activity -the ability to fight infections caused by fungi- of the lectins present in the latex of this plant. This potential antifungal activity opens an interesting line of research in finding new uses for latex proteins of E. trigona against various diseases.

Lectins currently represent the most versatile group of plant proteins used in basic and applied biological and biomedical research. They offer a broad range of potential applications in biotechnology, mainly in three areas: research into bioactive proteins, plant cultures for improving the defense system against predators, and biomedicine for diagnosis and therapeutic treatment. In fact, a lectin extracted from mistletoe is the active substance, marketed as Iscador and Isorel, currently used in treating cancer. Lectins can also display anti-viral, antibacterial, anti-fungal and insecticide activity.


Story Source:

The above story is based on materials provided by Basque Research. Note: Materials may be edited for content and length.


Cite This Page:

Basque Research. "Antitumour proteins identified in the latex of the plant Euphorbia trigona." ScienceDaily. ScienceDaily, 21 June 2012. <www.sciencedaily.com/releases/2012/06/120621113333.htm>.
Basque Research. (2012, June 21). Antitumour proteins identified in the latex of the plant Euphorbia trigona. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/06/120621113333.htm
Basque Research. "Antitumour proteins identified in the latex of the plant Euphorbia trigona." ScienceDaily. www.sciencedaily.com/releases/2012/06/120621113333.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins