Circumcision For Prevention Of HIV: New Analysis Demonstrates Cost-effectiveness

The researchers carried out a set of calculations, using the results from their major ‘Orange Farm trialâ€TM, and making other assumptions based on data from elsewhere. Their mathematical model was based on a hypothetical group of 1,000 men, all of whom would be circumcised. The researchers calculated that in such a hypothetical group, the cost of providing male circumcision, per HIV infection prevented, would be around $180. Overall, this procedure seemed to be cost-saving when the cost of HIV treatment was considered; around $2.4 million would be saved for the 1,000 men circumcised.

The overall cost of male circumcision, per HIV infection prevented, is reasonable as compared to the costs of other strategies for prevention of HIV. There would also be implications for HIV prevention programs in other African countries.

The ground-breaking Orange Farm study was first published in PLoS Medicine in October 2005.

Within the last few days, it has been announced that two further trials of circumcision for HIV prevention, conducted by research teams in East Africa, have been stopped early. It became clear that the rate of new HIV infections was much lower in circumcised men, compared with uncircumcised men. It was therefore considered that continuing the trials would be unethical. The full results of the East African tr ials have not yet been published.

Researchers do not suggest that being circumcised eliminates the risk of HIV infection. It merely reduces it. Other measures to prevent infection are still essential.

Citation: Kahn JG, Marseille E, Auvert B (2006) Cost-effectiveness of male circumcision for HIV prevention in a South African setting. PLoS Med 3(12): e517. (http://dx.doi.org/10.1371/journal.pmed.0030517)