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Timing Is Everything When Treating Viral Infections

Date:
September 19, 2007
Source:
Journal of Clinical Investigation
Summary:
A new study has indicated that the timing of treatment with an immune-modifying drug, relative to when a mouse becomes infected with a virus, is crucial in determining whether the treatment is effective or not. If mice were treated with an antibody before being infected, or within 48 hours of being infected, with a particular virus, the immune response failed to clear the virus. By contrast, if treatment was delayed until more than 72 hours after infection the immune response was enhanced and rapidly cleared the virus.
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A new study by Robert Mittler and colleagues from Emory University School of Medicine, Atlanta, has indicated that the timing of treatment with an immune-modifying drug, relative to when a mouse becomes infected with a virus, is crucial in determining whether the treatment is effective or not.

If mice were treated with an antibody that stimulates the molecule CD137 (also known as 4-1BB) before being infected, or within 48 hours of being infected, with the virus LCMV Armstrong the immune response failed to clear the virus.

By contrast, if treatment was delayed until more than 72 hours after infection the immune response was enhanced and rapidly cleared the virus. Further analysis revealed that early treatment with CD137-specific antibody caused large numbers of immune cells known as CD4+ and CD8+ T cells to die by day 8 of the infection. These data have important implications for the development of CD137 agonists as vaccine adjuvants, something that is currently ongoing.

Article: Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time-dependent


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Journal of Clinical Investigation. "Timing Is Everything When Treating Viral Infections." ScienceDaily. ScienceDaily, 19 September 2007. <www.sciencedaily.com/releases/2007/09/070914090707.htm>.
Journal of Clinical Investigation. (2007, September 19). Timing Is Everything When Treating Viral Infections. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2007/09/070914090707.htm
Journal of Clinical Investigation. "Timing Is Everything When Treating Viral Infections." ScienceDaily. www.sciencedaily.com/releases/2007/09/070914090707.htm (accessed May 23, 2017).

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