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AAT drug may prevent deadly infections, researchers find

Date:
January 6, 2015
Source:
American Associates, Ben-Gurion University of the Negev
Summary:
In a recent study, mice were directly infected with highly lethal live bacteria, sepsis and peritonitis. The initial aim was to exclude the possibility that AAT, might worsen infections in patients who are being treated with the drug. AAT is currently being used to treat new clinical indications like type 1 diabetes, emphysema and graft versus host disease. Instead, a research group unexpectedly discovered that the treated mice combated these lethal infections better than the untreated mice.
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Ben Gurion University of the Negev (BGU) researchers have discovered that alpha1-antitrypsin (AAT) could prevent deadly infections in immune system-compromised patients.

Their study, reported in the Journal of Infectious Diseases by Dr. Eli C. Lewis and his team of BGU researchers, examined the effectiveness of AAT treatment in halting bacterial colonization and spread. Bacterial infections can rapidly become severe and cause sepsis, multiple organ dysfunction and death, even with available antibiotics.

In the study, mice were directly infected with highly lethal live bacteria, sepsis and peritonitis. The initial aim was to exclude the possibility that AAT, an anti-inflammatory agent, might worsen infections in patients who are being treated with the drug. AAT is currently being used to treat new clinical indications like type 1 diabetes, emphysema and graft versus host disease (a condition that occurs with transplant rejection).

Instead, the BGU research group unexpectedly discovered that the treated mice combatted these lethal infections better than the untreated mice. The bacteria directly introduced were practically eradicated by AAT therapy within 24 hours. According to the researchers, "There were barely enough bacteria left to grow colonies on a plate."

"Imagine if weak patients receive AAT prior to prolonged hospitalization in bacteria-rich hospital facilities," says Dr. Lewis, head of the clinical islet laboratory at BGU. "Considering the current frustration with antibiotic development rate compared to bacterial resistance rates, the clinical implications are immense. There is significant demand for the availability of a safe, preemptive, readily accessible approach."

The molecule AAT is naturally produced in the human liver, particularly during inflammatory bouts. It has been known to reduce excessive inflammation and preserve injured tissues.

The BGU team is now working on deciphering the mechanisms behind these favorable outcomes, which will be published in future studies.


Story Source:

Materials provided by American Associates, Ben-Gurion University of the Negev. Note: Content may be edited for style and length.


Journal Reference:

  1. Z. Kaner, D. E. Ochayon, G. Shahaf, B. M. Baranovski, N. Bahar, M. Mizrahi, E. C. Lewis. Acute Phase Protein  1-Antitrypsin Reduces the Bacterial Burden in Mice by Selective Modulation of Innate Cell Responses. Journal of Infectious Diseases, 2014; DOI: 10.1093/infdis/jiu620

Cite This Page:

American Associates, Ben-Gurion University of the Negev. "AAT drug may prevent deadly infections, researchers find." ScienceDaily. ScienceDaily, 6 January 2015. <www.sciencedaily.com/releases/2015/01/150106154612.htm>.
American Associates, Ben-Gurion University of the Negev. (2015, January 6). AAT drug may prevent deadly infections, researchers find. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/01/150106154612.htm
American Associates, Ben-Gurion University of the Negev. "AAT drug may prevent deadly infections, researchers find." ScienceDaily. www.sciencedaily.com/releases/2015/01/150106154612.htm (accessed May 23, 2017).

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