Science News
from research organizations

Study examines NSAID use, risk of anastomotic failure following surgery

Date:
January 21, 2015
Source:
The JAMA Network Journals
Summary:
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with an increased risk of anastomotic leak at the surgical junction in patients undergoing nonelective colorectal procedures, according to a report.
Share:
FULL STORY

Use of nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with an increased risk of anastomotic leak at the surgical junction in patients undergoing nonelective colorectal procedures, according to a report published online by JAMA Surgery.

NSAIDs are a broad class of drugs used to relieve pain and inflammation and have long been used to treat postoperative pain. Their postoperative use has expanded with the recent development of intravenous formulations and because NSAIDs avoid the adverse effects of opioid pain relievers such as respiratory depression, impaired motility of the gastrointestinal tract and others, according to background in the study.

Timo W. Hakkarainen, M.D., M.S., of the University of Washington Medical Center, Seattle, and coauthors examined postoperative NSAID use and anastomotic complications. The study included 13,082 patients undergoing bariatric or colorectal surgery at 47 hospitals in Washington state from 2006 through 2010 and used data from the Surgical Care and Outcomes Assessment Program.

The authors report that 3,158 (24.1 percent) of the 13,082 patients received NSAIDs postoperatively. Patients who received NSAIDs were younger, had lower levels of co-exiting illnesses, a lower cardiac risk index and had elective procedures more frequently than those patients who did not receive NSAIDs.

Results show the overall 90-day rate of anastomotic leaks was 4.3 percent for all patients (4.8 percent in the NSAID group and 4.2 percent in the non-NSAID group). NSAIDs were associated with a 24 percent increased risk for anastomotic leak after risk adjustment and this association was isolated to nonelective (urgent) colorectal surgery, where the leak rate was 12.3 percent in the NSAID group and 8.3 percent in the non-NSAID group. There was no effect for patients undergoing elective (scheduled) colorectal or bariatric surgery, according to the results.

"The results of this large statewide cohort study show that, among patients undergoing nonelective colorectal resection, postoperative NSAID administration is associated with a significantly increased risk for anastomotic complications. Given that other analgesic regimens are effective and well tolerated, these data may be enough for some surgeons to alter practice patterns," the study concludes.


Story Source:

Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. David R. Flum, MD, MPH et al. Nonsteroidal Anti-inflammatory Drugs and the Risk for Anastomotic Failure: A Report From Washington State’s Surgical Care and Outcomes Assessment Program (SCOAP). JAMA Surgery, January 2015 DOI: 10.1001/jamasurg.2014.2239

Cite This Page:

The JAMA Network Journals. "Study examines NSAID use, risk of anastomotic failure following surgery." ScienceDaily. ScienceDaily, 21 January 2015. <www.sciencedaily.com/releases/2015/01/150121114903.htm>.
The JAMA Network Journals. (2015, January 21). Study examines NSAID use, risk of anastomotic failure following surgery. ScienceDaily. Retrieved May 27, 2017 from www.sciencedaily.com/releases/2015/01/150121114903.htm
The JAMA Network Journals. "Study examines NSAID use, risk of anastomotic failure following surgery." ScienceDaily. www.sciencedaily.com/releases/2015/01/150121114903.htm (accessed May 27, 2017).

RELATED STORIES