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Laparoscopic hysterectomy with morcellation may be safer than abdominal procedure, new study indicates

Date:
March 24, 2015
Source:
Elsevier
Summary:
A study has compared the relative risks of laparoscopic hysterectomy (with morcellation) with abdominal surgery for hysterectomy in premenopausal women undergoing surgery for presumed uterine fibroids. Examining short- and long-term complications, quality of life, and overall mortality, they found that abdominal surgery carries a higher risk of complications, decreased quality of life, and death.
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In a new study published in the American Journal of Obstetrics & Gynecology, researchers from The University of North Carolina at Chapel Hill compared the relative risks of laparoscopic hysterectomy (with morcellation) with abdominal surgery for hysterectomy in premenopausal women undergoing surgery for presumed uterine fibroids. Examining short- and long-term complications, quality of life, and overall mortality, they found that abdominal surgery carries a higher risk of complications, decreased quality of life, and death.

Hysterectomy is the most common gynecologic procedure performed on non-pregnant women in the United States, and a diagnosis of fibroids (leiomyomata) accounts for many of these procedures. Minimally invasive surgery is being used more frequently because of its many advantages, including less pain and shorter length of hospital stay. But in some cases, the uterus cannot be removed without morcellation, or cutting it into pieces to fit through small incisions. However, morcellation has come under scrutiny because of concerns that if an undetected malignancy (leiomyosarcoma) is present, it may be dispersed into the pelvis and abdomen, resulting in the spread of cancer and increased mortality. This concern resulted in an FDA notification that discouraged morcellation during hysterectomy.

Given the rarity of leiomyosarcoma, a randomized trial comparing mortality after different types of hysterectomy is not feasible. Consequently, the UNC researchers used decision-tree analysis, which can compare the morbidity and mortality outcomes from a choice of surgical approaches, in this case laparoscopic versus abdominal surgery. The model evaluates outcomes according to the probability of complications specific to laparoscopic and abdominal surgery. Researchers used results from published studies, selecting inputs from the highest quality and most recent studies to reflect advances in surgical practice. Ten studies were used to estimate the incidence of malignant leiomyosarcoma in women undergoing surgery for presumed fibroids.

"Our decision analysis predicted lower overall mortality from laparoscopic hysterectomy with morcellation than abdominal hysterectomy for treating the presumed fibroid uterus in premenopausal women," explained lead investigator Matthew T. Siedhoff, MD, MSCR. "Laparoscopic hysterectomy with morcellation was also associated with fewer postoperative complications and improved quality of life."

Using a hypothetical cohort of 100,000 women over a five-year time horizon, the investigators found that, while there would be more deaths from malignant leiomyosarcoma with laparoscopic surgery (98 vs. 103 per 100,000), there were more hysterectomy-related deaths, for example, from blood clots after surgery, with the abdominal procedure (32 vs. 12 per 100,000).

Sensitivity analyses were performed to assess the robustness of the assumptions in the decision model, including surgical complications, the probability of leiomyosarcoma, and probability of death from hysterectomy. The range of clinical outcomes (e.g. transfusion, wound infection, etc.) was evaluated by varying the input for each clinical event to its minimum and maximum.

Editor-in-Chief for Gynecology of the American Journal of Obstetrics & Gynecology Ingrid Nygaard, MD, MS, Professor of Obstetrics and Gynecology at the University of Utah, commented that "No decision analysis is ever the 'final word' and this one in this month's AJOG is no different. New data will continue to be added to the literature and the conclusions might stand as they are or change. But, most importantly, Siedhoff et al remind us to keep the big picture in mind, to balance risks and benefits of different procedures, and to work vigilantly to decrease the impact of risks to the extent possible."


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Materials provided by Elsevier. Note: Content may be edited for style and length.


Journal Reference:

  1. Matthew T. Siedhoff, MD, MSCR; Stephanie B. Wheeler, PhD, MPH; Sarah E. Rutstein, PhD; Elizabeth J. Geller, MD; Kemi M. Doll, MD; Jennifer M. Wu, MD, MPH; and Daniel L. Clarke-Pearson, MD. Laparoscopic hysterectomy with morcellation versus abdominal hysterectomy for presumed fibroids in premenopausal women: A decision analysis. American Journal of Obstetrics & Gynecology, March 2015 DOI: 10.1016/j.ajog.2015.03.006

Cite This Page:

Elsevier. "Laparoscopic hysterectomy with morcellation may be safer than abdominal procedure, new study indicates." ScienceDaily. ScienceDaily, 24 March 2015. <www.sciencedaily.com/releases/2015/03/150324111504.htm>.
Elsevier. (2015, March 24). Laparoscopic hysterectomy with morcellation may be safer than abdominal procedure, new study indicates. ScienceDaily. Retrieved May 25, 2017 from www.sciencedaily.com/releases/2015/03/150324111504.htm
Elsevier. "Laparoscopic hysterectomy with morcellation may be safer than abdominal procedure, new study indicates." ScienceDaily. www.sciencedaily.com/releases/2015/03/150324111504.htm (accessed May 25, 2017).

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