New knowledge on bone tissue, its role in bone strength or weakness
New insights into bone material properties, the various mineral, collagen and water compartments in bone, and the role of these properties in skeletal fragility
- Date:
- June 29, 2015
- Source:
- International Osteoporosis Foundation
- Summary:
- Leading experts in the field present the latest research on material properties of bone and how these can impart resilience or fragility to the skeleton. This new knowledge will aide in understanding both the hierarchical structure of bone and its importance to overall bone health.
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While there is good understanding of how bone mass, and more recently bone architecture, affects fracture risk, far less is known about the material properties of bone, or how these can impart resilience or fragility to the skeleton. This is changing thanks to the development of new state-of-the-art imaging and other technologies which now allow researchers to gain new insights into the different material properties of bone and their role in bone fragility.
Bringing together eight invited contributions by the field's leading experts, a special issue of Calcified Tissue International & Musculoskeletal Research now provides a comprehensive overview of the latest and most exciting findings in this area of skeletal research. The issue is co-edited by Drs. David B. Burr and Matthew R. Allen of the Department of Anatomy and Cell Biology, Indiana University School of Medicine.
Drs. Burr and Allen, the co-editors, challenged the authors not only to review the current state of knowledge about their specific topic, but to help propel research forward by highlighting key questions that remain to be addressed. "Our hope is that this will stimulate the new wave of work aimed at understanding both the hierarchical structure of bone and its importance to overall bone health."
Story Source:
Materials provided by International Osteoporosis Foundation. Note: Content may be edited for style and length.
Journal References:
- David B. Burr, Matthew R. Allen. Foreword: Calcified Tissue International and Musculoskeletal Research Special Issue. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-0012-7
- Wolfgang Wagermaier, Klaus Klaushofer, Peter Fratzl. Fragility of Bone Material Controlled by Internal Interfaces. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-9978-4
- David P. Fyhrie, Blaine A. Christiansen. Bone Material Properties and Skeletal Fragility. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-9997-1
- Patrick Garnero. The Role of Collagen Organization on the Properties of Bone. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-9996-2
- Mitsuru Saito, Keishi Marumo. Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-9985-5
- Stacyann Morgan, Atharva A. Poundarik, Deepak Vashishth. Do Non-collagenous Proteins Affect Skeletal Mechanical Properties? Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-0016-3
- S. R. Stock. The Mineral–Collagen Interface in Bone. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-9984-6
- Mathilde Granke, Mark D. Does, Jeffry S. Nyman. The Role of Water Compartments in the Material Properties of Cortical Bone. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-9977-5
- Y. Bala, E. Seeman. Bone’s Material Constituents and their Contribution to Bone Strength in Health, Disease, and Treatment. Calcified Tissue International, 2015; DOI: 10.1007/s00223-015-9971-y
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