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New treatment may help neonatal liver disease associated with parenteral nutrition

Date:
July 28, 2015
Source:
American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
Summary:
Exogenous glucagon-like peptide 2 (GLP-2) treatment may help fight neonatal parenteral nutrition associated liver disease (PNALD), a new study suggests.
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A new study finds that exogenous glucagon-like peptide 2 (GLP-2) treatment may help fight neonatal parenteral nutrition-associated liver disease (PNALD).

The study, published in the OnlineFirst version of the Journal of Parenteral and Enteral Nutrition (JPEN), the research journal of the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), provided neonatal piglets with 17 days of parenteral nutrition therapy and either GLP-2 treatment or saline control. In a previous study, the researchers found that GLP-2 therapy improved bile flow and serum markers of cholestasis.

In this follow-up study, the authors found that GLP-2 treatment was associated with alterations in bile acid profiles and the hepatic expression of genes involved in bile acid metabolism, which may be beneficial for PNALD. The data suggest that GLP-2 improves the excretion of toxic bile acids while stimulating liver growth, perhaps via the synthesis of more hepatoprotective bile acids. These findings support a beneficial role for GLP-2 as a novel therapy in PNALD.


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Materials provided by American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). Note: Content may be edited for style and length.


Journal Reference:

  1. David W. Lim, Paul W. Wales, Si Mi, Jason Y. K. Yap, Jonathan M. Curtis, Diana R. Mager, Vera C. Mazurak, Pamela R. Wizzard, David L. Sigalet, and Justine M. Turner. Glucagon-Like Peptide-2 Alters Bile Acid Metabolism in Parenteral Nutrition–Associated Liver Disease. Journal of Parenteral and Enteral Nutrition, July 2015 DOI: 10.1177/0148607115595596

Cite This Page:

American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). "New treatment may help neonatal liver disease associated with parenteral nutrition." ScienceDaily. ScienceDaily, 28 July 2015. <www.sciencedaily.com/releases/2015/07/150728091734.htm>.
American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). (2015, July 28). New treatment may help neonatal liver disease associated with parenteral nutrition. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150728091734.htm
American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). "New treatment may help neonatal liver disease associated with parenteral nutrition." ScienceDaily. www.sciencedaily.com/releases/2015/07/150728091734.htm (accessed May 23, 2017).

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