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Afatinib: Added benefit in certain mutations confirmed

Lung cancer patients with Del19 mutation benefit most

Date:
August 20, 2015
Source:
Institute for Quality and Efficiency in Health Care
Summary:
In advanced non-small cell lung cancer, the new tyrosine-kinase inhibitor is more effective than combination chemotherapy in patients with certain mutations, reviewers report.
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Afatinib (trade name: Giotrif) has been approved since September 2013 for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating EGF receptor mutations who have not been treated with an EGF receptor tyrosine-kinase inhibitor (EGFR TKI). After a first early benefit assessment in February 2014, the German Institute for Quality and Efficiency in Health Care (IQWiG) now reexamined whether the drug offers an added benefit over the appropriate comparator therapy. The new benefit assessment was conducted because a limitation of the corresponding decision by the Federal Joint Commission (G-BA) expired in May 2015.

The current assessment was based on a new data cut-off of the study already investigated in 2014. Evaluable data were only available for treatment-naive patients in relatively good general condition (ECOG PS 0 or 1). There is still an indication of a major added benefit of afatinib in patients with the EGFR mutation Del19, and a hint of a minor added benefit in patients with L858R mutation. In patients with other EGFR mutations, the Institute now no longer detected an indication, but only a hint of lesser benefit versus the comparator therapy. The pharmaceutical company presented no relevant data for pretreated patients.


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Materials provided by Institute for Quality and Efficiency in Health Care. Note: Content may be edited for style and length.


Cite This Page:

Institute for Quality and Efficiency in Health Care. "Afatinib: Added benefit in certain mutations confirmed: Lung cancer patients with Del19 mutation benefit most." ScienceDaily. ScienceDaily, 20 August 2015. <www.sciencedaily.com/releases/2015/08/150820125837.htm>.
Institute for Quality and Efficiency in Health Care. (2015, August 20). Afatinib: Added benefit in certain mutations confirmed: Lung cancer patients with Del19 mutation benefit most. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/08/150820125837.htm
Institute for Quality and Efficiency in Health Care. "Afatinib: Added benefit in certain mutations confirmed: Lung cancer patients with Del19 mutation benefit most." ScienceDaily. www.sciencedaily.com/releases/2015/08/150820125837.htm (accessed May 23, 2017).

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