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Research team synthesizes new cancer fighter

Thailanstatin A disrupts disease by inhibiting DNA-editing machinery

Date:
June 20, 2016
Source:
Rice University
Summary:
Scientists have synthesized a novel anti-cancer agent, Thailanstatin A, which was originally isolated from a bacterial species collected in Thailand.
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A schematic shows the synthesized anti-cancer agent Thailanstatin A. The Rice University lab of synthetic chemist K.C. Nicolaou has synthesized the molecule found in bacteria native to Thailand.
Credit: Nicolaou Group/Rice University

Rice University scientists have synthesized a novel anti-cancer agent, Thailanstatin A, which was originally isolated from a bacterial species collected in Thailand.

Thailanstatin A fights cancer by inhibiting the spliceosome, the machinery in the cell that edits messenger RNA after transcription from DNA but before its translation into proteins.

Rice synthetic chemist K.C. Nicolaou and his group reported their success in the Journal of the American Chemical Society.

Nicolaou and his colleagues specialize in the synthesis of potential therapeutic agents that are found in nature but in amounts too small for thorough biological evaluation or clinical use. He is best known for the total synthesis of paclitaxel, a drug commonly used to treat a number of cancers.

The researchers explained that the spliceosome, a complex of proteins and ribonucleoproteins that regulate DNA splicing, is more active and displays higher mutation rates in cancer cells than in healthy cells, which makes it a valid target for investigation.

"This cellular machinery edits mRNA as it emerges from the transcription of DNA through site-specific removal of introns (noncoding regions of DNA) and splicing the remaining exon (coding) sequences prior to translation," Nicolaou said. "Thailanstatin A interferes with this mechanism."

He said the synthesis of Thailanstatin A, first isolated from burkholderia thailandensis bacteria, opens the way to construct and test variations of the molecule. "These studies will be directed toward optimization of the pharmacological properties of this new natural product as part of a drug discovery and development program targeting new therapies for cancer," Nicolaou said.

The program can take two directions, he said: one directed toward high-potency compounds that could be used as payloads for antibody drug conjugates and the other toward selective agents that can kill cancer cells with minimal damage to healthy cells.

The first paradigm is currently a frontier approach for the development of targeted and personalized cancer therapies, while the second represents a more traditional approach that could also lead to powerful anti-cancer drugs, Nicolaou said. "Thailanstatin A exhibits just the right potency to be diverted to either approach through a reiterative molecular design, chemical synthesis and biological evaluation process," he said.

"We're excited about this new molecule and its analogs because of their unique biological properties and the prospects of working collaboratively with industrial and academic partners to advance them toward the clinic," Nicolaou said.


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Materials provided by Rice University. Note: Content may be edited for style and length.


Journal Reference:

  1. K. C. Nicolaou, Derek Rhoades, Manjunath Lamani, Manas R. Pattanayak, S. Mothish Kumar. Total Synthesis of Thailanstatin A. Journal of the American Chemical Society, 2016; DOI: 10.1021/jacs.6b04781

Cite This Page:

Rice University. "Research team synthesizes new cancer fighter: Thailanstatin A disrupts disease by inhibiting DNA-editing machinery." ScienceDaily. ScienceDaily, 20 June 2016. <www.sciencedaily.com/releases/2016/06/160620112052.htm>.
Rice University. (2016, June 20). Research team synthesizes new cancer fighter: Thailanstatin A disrupts disease by inhibiting DNA-editing machinery. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2016/06/160620112052.htm
Rice University. "Research team synthesizes new cancer fighter: Thailanstatin A disrupts disease by inhibiting DNA-editing machinery." ScienceDaily. www.sciencedaily.com/releases/2016/06/160620112052.htm (accessed May 24, 2017).

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