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Immunotherapy benefits relapsed stem cell transplant recipients

Date:
July 13, 2016
Source:
Dana-Farber Cancer Institute
Summary:
Using repeated doses of an immunotherapy drug can restore a complete remission for some relapsed stem cell transplant recipients, new research indicates.
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For many patients with advanced blood cancers, a stem-cell transplant can drive the disease into remission. However, about one-third of these patients experience a relapse and face a very poor prognosis.

But a Dana-Farber Cancer Institute study published in the New England Journal of Medicine suggests that a new treatment approach, using repeated doses of an immunotherapy drug, can restore a complete remission for some patients in this predicament. This strategy could potentially prevent such relapses in the future.

An immune checkpoint-blocking drug approved for metastatic melanoma, ipilimumab, was given to patients with relapsed hematologic malignancies in an effort to revive the tumor-fighting powers of the donors' transplanted immune systems. A weakening of the transplanted immune response over time is believed to allow the cancers to recur.

The patients received varying doses of ipilimumab repeatedly for up to one year. Ipilimumab blocks an immune checkpoint, CTLA4 that helps cancer cells evade the immune defenses.

"We believe the donor immune cells are present but can't recognize the tumor cells because of inhibitory signals that disguise them," said Matthew Davids, MD MMSc, a member of the Division of Hematologic Malignancies at Dana-Farber and first author of the study. "By blocking the checkpoint, you allow the donor cells to see the cancer cells." Ipilumumab has been used primarily in treating advanced melanoma, but in the new study, it proved effective for blood cancers in the post-transplant setting.

A total of 28 patients with relapsed leukemia, lymphoma, multiple myeloma, and myelodysplastic tumors were enrolled in the multicenter phase 1, investigator-initiated trial.

Among the 22 patients who were treated with the highest dose of ipilimumab, five had a complete response, meaning the cancer was undetectable, and two patients had a partial response, with the tumors shrinking. Six others, who did not qualify as having responses, nevertheless had a decrease in their tumor burden. Altogether, ipilimumab therapy reduced cancer in 59 percent of the relapsed patients.

Among the complete responders were three patients with a hard-to-treat form of leukemia that affects the skin. Such "extramedullary myeloid leukemias," which aren't confined to the bone marrow and typically don't respond to standard therapies, may be particularly sensitive to checkpoint-blocking drugs, the authors noted.

Because checkpoint-blocking drugs like ipilimumab rev up the immune system by releasing molecular brakes that restrain T cells, there was concern that the treatment could stimulate graft-versus-host disease (GVHD), a serious transplant complication, along with its graft-versus-tumor effect.

"But we didn't see that," said Davids. Only four of 28 patients developed GVHD that prevented further treatment, and they all responded to corticosteroid drugs which controlled the GVHD. Six other patients had adverse effects typical of ipilimumab treatment, and one patient died from an immune-related adverse event.

The investigators said the encouraging results have set the stage for larger trials of checkpoint blockade in this population of relapsed post-transplant patients. Further research is planned to determine whether immunotherapy drugs could be given to high-risk patients to prevent relapse.


Story Source:

Materials provided by Dana-Farber Cancer Institute. Note: Content may be edited for style and length.


Journal Reference:

  1. Matthew S. Davids, Haesook T. Kim, Pavan Bachireddy, Caitlin Costello, Rebecca Liguori, Alexandra Savell, Alexander P. Lukez, David Avigan, Yi-Bin Chen, Peter McSweeney, Nicole R. LeBoeuf, Michael S. Rooney, Michaela Bowden, Chensheng W. Zhou, Scott R. Granter, Jason L. Hornick, Scott J. Rodig, Masahiro Hirakawa, Mariano Severgnini, F. Stephen Hodi, Catherine J. Wu, Vincent T. Ho, Corey Cutler, John Koreth, Edwin P. Alyea, Joseph H. Antin, Philippe Armand, Howard Streicher, Edward D. Ball, Jerome Ritz, Asad Bashey, Robert J. Soiffer. Ipilimumab for Patients with Relapse after Allogeneic Transplantation. New England Journal of Medicine, 2016; 375 (2): 143 DOI: 10.1056/NEJMoa1601202

Cite This Page:

Dana-Farber Cancer Institute. "Immunotherapy benefits relapsed stem cell transplant recipients." ScienceDaily. ScienceDaily, 13 July 2016. <www.sciencedaily.com/releases/2016/07/160713214427.htm>.
Dana-Farber Cancer Institute. (2016, July 13). Immunotherapy benefits relapsed stem cell transplant recipients. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2016/07/160713214427.htm
Dana-Farber Cancer Institute. "Immunotherapy benefits relapsed stem cell transplant recipients." ScienceDaily. www.sciencedaily.com/releases/2016/07/160713214427.htm (accessed May 28, 2017).

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