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A new pathogen in Africa causes anthrax-like disease in wild and domestic animals

Date:
September 8, 2016
Source:
PLOS
Summary:
A new study reports that a related bacillus with distinct genetic and biological characteristics causes anthrax-like disease in chimps, gorillas, elephants, and goats from four different African countries. Increased surveillance for this pathogen is needed to evaluate its impact on animal and human health.
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Anthrax is caused by Bacillus anthracis, a pathogen that causes potentially fatal disease in most mammals, including humans. A study published in PLOS Neglected Tropical Diseases reports that a related bacillus with distinct genetic and biological characteristics causes anthrax-like disease in chimps, gorillas, elephants, and goats from four different African countries. Increased surveillance for this pathogen is needed to evaluate its impact on animal and human health.

Bacillus anthracis and its two close relatives, Bacillus thuringiensis and Bacillus cereus, are spore-forming bacteria naturally found in soil throughout much of the world. Their ability to cause disease depends on so-called virulence factors, some of which are encoded on plasmids (smaller parts of genetic material that can relatively easily be exchanged between bacteria) rather than the single chromosome. B. anthracis contains two such plasmids called pXO1 and pXO2, and both are required for full virulence.

Fabian Leendertz, from the Robert Koch Institute in Berlin, Germany, and colleagues, had previously described an unusual B. cereus bacterium isolated from a sick chimpanzee in Ivory Coast. This isolate possessed both the pXO1 and pXO2 'anthrax' plasmids, but its chromosome was closely related to B. cereus and not to B. anthracis. Because the bacterium appeared to have evolved from a B. cereus strain independently from the classic B. anthracis strains and established a B. anthracis lifestyle, the researchers called it 'B. cereus biovar (bv) anthracis'.

In the current study, they describe the origin and detailed molecular analysis of four additional B. cereus bv anthracis isolates. The bacteria were isolated from a goat, gorillas, a chimpanzee, and an elephant in Cameroon, the Central African Republic, and the Democratic Republic of Congo. All animals were sick or dead. Like the chimpanzee isolate from Ivory Coast, the new isolates shared the two virulence plasmids pXO1 and pXO2 with B. anthracis but chromosomal features with B. cereus.

More detailed analysis of their genomes suggested that the B. cereus bv anthracis isolates form a 'clade', which means they share a common ancestor. B. anthracis isolates, on the other hand, have a different ancestor and belong to a different clade. All B. cereus bv anthracis isolates possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and carry an intact copy of a gene mutated in B. anthracis, which enables them to produce a second outer shell composed of hyaluronic acid.

While closely related, the individual B. cereus bv anthracis isolates also differed amongst each other, for example in their ability to move in liquid medium and their resistance or sensitivity to penicillin, suggesting that this clade has existed and evolved for a while.

Their findings, the researchers say, "show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity." They call for systematic surveillance "to establish the impact of these pathogenic bacteria on threatened wildlife species," and warn that "consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans."


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Journal Reference:

  1. Kym S. Antonation, Kim Grützmacher, Susann Dupke, Philip Mabon, Fee Zimmermann, Felix Lankester, Tianna Peller, Anna Feistner, Angelique Todd, Ilka Herbinger, Hélène M. de Nys, Jean-Jacques Muyembe-Tamfun, Stomy Karhemere, Roman M. Wittig, Emmanuel Couacy-Hymann, Roland Grunow, Sébastien Calvignac-Spencer, Cindi R. Corbett, Silke R. Klee, Fabian H. Leendertz. Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa—Chromosomal Monophyly and Broad Geographic Distribution. PLOS Neglected Tropical Diseases, 2016; 10 (9): e0004923 DOI: 10.1371/journal.pntd.0004923

Cite This Page:

PLOS. "A new pathogen in Africa causes anthrax-like disease in wild and domestic animals." ScienceDaily. ScienceDaily, 8 September 2016. <www.sciencedaily.com/releases/2016/09/160908150850.htm>.
PLOS. (2016, September 8). A new pathogen in Africa causes anthrax-like disease in wild and domestic animals. ScienceDaily. Retrieved May 25, 2017 from www.sciencedaily.com/releases/2016/09/160908150850.htm
PLOS. "A new pathogen in Africa causes anthrax-like disease in wild and domestic animals." ScienceDaily. www.sciencedaily.com/releases/2016/09/160908150850.htm (accessed May 25, 2017).

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