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Genetic variant linked to overactive inflammatory response

Date:
February 28, 2017
Source:
Cardiff University
Summary:
Genetic variation is the reason why some immune systems overreact to viruses, researchers have discovered.
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Researchers at Cardiff University have discovered that genetic variation is the reason why some immune systems overreact to viruses.

Previous research had already revealed that a gene called Ifitm3 influences how sensitive people are to the influenza virus, with a variant form of the gene making cells more susceptible to viral infection. The new research reveals that Ifitm3 also plays an important role in controlling the extent of the inflammatory response triggered by virus infection.

The study suggests that individuals with deficiencies in Ifitm3 may have an overactive immune response to viral infection and may therefore be helped by a combination of anti-inflammatory drugs in addition to medicine that directly targets the virus.

World-wide the frequency of the variant Ifitm3 gene is 1 in 400, although it is much more common in certain ethnicities.

Dr Ian Humphreys from Cardiff University's School of Medicine said: "Now we know that genetic make-up influences how the immune system copes with infections, not only by influencing how the body controls an infection but also by controlling how strongly the body's immune system reacts, we can design therapeutic strategies for individuals who are seriously ill with infections, which are tailored to the individual based on their genetic profile."

The data were collected using immune cells from mice with and without the variant form of Ifitm3, to observe how the immune system responds to a virus called cytomegalovirus. The results could also be relevant for other viral infections such as influenza epidemics/pandemics.


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Materials provided by Cardiff University. Note: Content may be edited for style and length.


Journal Reference:

  1. Maria A. Stacey, Simon Clare, Mathew Clement, Morgan Marsden, Juneid Abdul-Karim, Leanne Kane, Katherine Harcourt, Cordelia Brandt, Ceri A. Fielding, Sarah E. Smith, Rachael S. Wash, Silvia Gimeno Brias, Gabrielle Stack, George Notley, Emma L. Cambridge, Christopher Isherwood, Anneliese O. Speak, Zoë Johnson, Walter Ferlin, Simon A. Jones, Paul Kellam, Ian R. Humphreys. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation, 2017; DOI: 10.1172/JCI84889

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Cardiff University. "Genetic variant linked to overactive inflammatory response." ScienceDaily. ScienceDaily, 28 February 2017. <www.sciencedaily.com/releases/2017/02/170228131011.htm>.
Cardiff University. (2017, February 28). Genetic variant linked to overactive inflammatory response. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2017/02/170228131011.htm
Cardiff University. "Genetic variant linked to overactive inflammatory response." ScienceDaily. www.sciencedaily.com/releases/2017/02/170228131011.htm (accessed May 28, 2017).

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