Science News
from research organizations

Scientists discover new category of analgesic drugs that may treat neuropathic pain

Date:
March 29, 2017
Source:
Federation of American Societies for Experimental Biology
Summary:
New research suggests that a novel therapeutic target called LPCAT2 may prove effective against pain that is not receptive to the current treatments. This study has also revealed the existence of a platelet alleviating factor (PAF) pain loop, suggesting a possible role for PAF-receptor antagonists.
Share:
FULL STORY

New research published online in The FASEB Journal suggests that a novel therapeutic target called LPCAT2 may prove effective against pain that is not receptive to the current treatments. This study has also revealed the existence of a platelet alleviating factor (PAF) pain loop, suggesting a possible role for PAF-receptor antagonists.

"We hope this finding contributes to relief from neuropathic pain in all people," said Hideo Shindou, Ph.D., vice project leader at the Department of Lipid Signaling, National Center for Global Health and Medicine, in Tokyo, Japan. "We hope this candidate newly categorized analgesic drug will resolve human pain."

To make their discovery, Shindou and colleagues conducted experiments using two groups of mice. The first group (LPCAT2-KO mice) had a disrupted LPCAT2 gene, which normally encodes the synthesis of PAF. The other group consisted of normal mice. The researchers induced a partial sciatic ligation (PSL) model of neuropathic pain in both groups of mice. The PSL operation increased pain behaviors in WT mice, but not in LPCAT2-KO mice. These findings present a new concept of analgesic drug development for neuropathic pain through the inhibition of PAF biosynthetic enzyme, LPCAT2, and reevaluation of PAFR antagonists.

"The exciting thing about this discovery is that the results were unanticipated" said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "One has the sense that a new door has been opened to the therapeutics of neuropathic pain."


Story Source:

Materials provided by Federation of American Societies for Experimental Biology. Note: Content may be edited for style and length.


Journal Reference:

  1. Hideo Shindou, Seiji Shiraishi, Suzumi M. Tokuoka, Yoshikazu Takahashi, Takeshi Harayama, Takaya Abe, Kana Bando, Kanako Miyano, Yoshihiro Kita, Yasuhito Uezono, Takao Shimizu. Relief from neuropathic pain by blocking of the platelet-activating factor–pain loop. The FASEB Journal, 2017; fj.201601183R DOI: 10.1096/fj.201601183R

Cite This Page:

Federation of American Societies for Experimental Biology. "Scientists discover new category of analgesic drugs that may treat neuropathic pain." ScienceDaily. ScienceDaily, 29 March 2017. <www.sciencedaily.com/releases/2017/03/170329102442.htm>.
Federation of American Societies for Experimental Biology. (2017, March 29). Scientists discover new category of analgesic drugs that may treat neuropathic pain. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2017/03/170329102442.htm
Federation of American Societies for Experimental Biology. "Scientists discover new category of analgesic drugs that may treat neuropathic pain." ScienceDaily. www.sciencedaily.com/releases/2017/03/170329102442.htm (accessed May 24, 2017).

RELATED STORIES