Science News
from research organizations

Monthly high-dose vitamin D supplementation does not prevent cardiovascular disease

Date:
April 5, 2017
Source:
The JAMA Network Journals
Summary:
Monthly high-dose vitamin D supplementation does not prevent cardiovascular disease, results of a large randomized trial indicate.
Share:
FULL STORY

Results of a large randomized trial indicate that monthly high-dose vitamin D supplementation does not prevent cardiovascular disease, according to a study published by JAMA Cardiology.

Studies have reported increased incidence of cardiovascular disease (CVD) among individuals with low vitamin D status. To date, randomized clinical trials of vitamin D supplementation have not found an effect, possibly because of using too low a dose of vitamin D. Robert Scragg, M.B.B.S., Ph.D., of the University of Auckland, New Zealand, and colleagues randomly assigned adults (age 50 to 84 years) to receive oral vitamin D3 (n = 2,558; an initial dose of 200,000 IU, followed a month later by monthly doses of 100,000 IU) or placebo (n = 2,552) for a median of 3.3 years.

Of the 5,108 participants included in the primary analysis, the average age was 66 years; 25 percent were vitamin D deficient. Cardiovascular disease occurred in 303 participants (11.8 percent) in the vitamin D group and 293 participants (11.5 percent) in the placebo group. Similar results were seen for participants with vitamin D deficiency at study entry and for other outcomes such as heart attack, angina, heart failure, hypertension, and stroke.

The authors write that the results of this study do not support the use of monthly high-dose vitamin D for the prevention of CVD. "The effects of daily or weekly dosing on CVD risk require further study."


Story Source:

Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Robert Scragg, Alistair W. Stewart, Debbie Waayer, Carlene M. M. Lawes, Les Toop, John Sluyter, Judy Murphy, Kay-Tee Khaw, Carlos A. Camargo. Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study. JAMA Cardiology, 2017; DOI: 10.1001/jamacardio.2017.0175

Cite This Page:

The JAMA Network Journals. "Monthly high-dose vitamin D supplementation does not prevent cardiovascular disease." ScienceDaily. ScienceDaily, 5 April 2017. <www.sciencedaily.com/releases/2017/04/170405112026.htm>.
The JAMA Network Journals. (2017, April 5). Monthly high-dose vitamin D supplementation does not prevent cardiovascular disease. ScienceDaily. Retrieved May 8, 2017 from www.sciencedaily.com/releases/2017/04/170405112026.htm
The JAMA Network Journals. "Monthly high-dose vitamin D supplementation does not prevent cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2017/04/170405112026.htm (accessed May 8, 2017).