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Use of prefabricated blood vessels may revolutionize root canals

Date:
June 12, 2017
Source:
Oregon Health & Science University
Summary:
Researchers have developed a process by which they can engineer new blood vessels in teeth, creating better long-term outcomes for root canal patients and clinicians.
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While root canals are effective in saving a tooth that has become infected or decayed, this age-old procedure may cause teeth to become brittle and susceptible to fracture over time. Now researchers at OHSU in Portland, Oregon, have developed a process by which they can engineer new blood vessels in teeth, creating better long-term outcomes for patients and clinicians.

Their findings will publish online in the journal Scientific Reports on June 12, 2017.

More than 15 million root canals are conducted annually in the United States. The current procedure involves removing infected dental tissues and replacing them with synthetic biomaterials covered by a protective crown.

"This process eliminates the tooth's blood and nerve supply, rendering it lifeless and void of any biological response or defense mechanism. Without this functionality, adult teeth may be lost much sooner, which can result in much greater concerns, such as the need for dentures or dental implants," says principal investigator Luiz Bertassoni, D.D.S., Ph.D., assistant professor of restorative dentistry in the OHSU School of Dentistry, and assistant professor of biomedical engineering in the OHSU School of Medicine.

To address this issue, Bertassoni and colleagues used a 3D printing-inspired process -- based on their previous work fabricating artificial capillaries -- to create blood vessels in the lab. They placed a fiber mold made of sugar molecules across the root canal of extracted human teeth and injected a gel-like material, similar to proteins found in the body, filled with dental pulp cells. The researchers removed the fiber to make a long microchannel in the root canal and inserted endothelial cells isolated from the interior lining of blood vessels. After seven days, dentin-producing cells proliferated near the tooth walls and artificial blood vessels formed inside the tooth.

"This result proves that fabrication of artificial blood vessels can be a highly effective strategy for fully regenerating the function of teeth," says Bertassoni, who also serves as an honorary lecturer in Bioengineering at University of Sydney-School of Dentistry. "We believe that this finding may change the way that root canal treatments are done in the future."


Story Source:

Materials provided by Oregon Health & Science University. Note: Content may be edited for style and length.


Journal Reference:

  1. Avathamsa Athirasala, Fernanda Lins, Anthony Tahayeri, Monica Hinds, Anthony J. Smith, Christine Sedgley, Jack Ferracane, Luiz E. Bertassoni. A Novel Strategy to Engineer Pre-Vascularized Full-Length Dental Pulp-like Tissue Constructs. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-02532-3

Cite This Page:

Oregon Health & Science University. "Use of prefabricated blood vessels may revolutionize root canals." ScienceDaily. ScienceDaily, 12 June 2017. <www.sciencedaily.com/releases/2017/06/170612094039.htm>.
Oregon Health & Science University. (2017, June 12). Use of prefabricated blood vessels may revolutionize root canals. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2017/06/170612094039.htm
Oregon Health & Science University. "Use of prefabricated blood vessels may revolutionize root canals." ScienceDaily. www.sciencedaily.com/releases/2017/06/170612094039.htm (accessed March 28, 2024).

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