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Genetic predisposition to breast cancer due to non-BRCA mutations in Ashkenazi Jewish women

Date:
July 20, 2017
Source:
The JAMA Network Journals
Summary:
Genetic mutations in BRCA1 and BRCA2 increase the risk of breast and ovarian cancer in Ashkenazi Jewish women. A new article pexamines the likelihood of carrying another cancer-predisposing mutation in BRCA1, BRCA2 or another breast cancer gene among women of Ashkenazi Jewish ancestry with breast cancer who do not carry one of the founder mutations.
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Genetic mutations in BRCA1 and BRCA2 increase the risk of breast and ovarian cancer in Ashkenazi Jewish women. A new article published by JAMA Oncology examines the likelihood of carrying another cancer-predisposing mutation in BRCA1, BRCA2 or another breast cancer gene among women of Ashkenazi Jewish ancestry with breast cancer who do not carry one of the founder mutations.

Mary-Claire King, Ph.D., of the University of Washington, Seattle, and coauthors sequenced genomic DNA of 1,007 women of Ashkenazi Jewish ancestry with breast cancer for known and candidate breast cancer genes.

Of the 1,007 patients in the study, 903 had none of the three founder mutations in BRCA1 or BRCA2. Of those 903 patients, seven (0.8 percent) carried a different mutation in BRCA1 or BRCA2 and 31 (3.4 percent) carried a damaging mutation in another breast cancer gene, according to the results.

The study notes two limitations, including that only genes known or suspected to harbor mutations increasing the risk of breast cancer were sequenced.

"Ashkenazi Jewish patients with breast cancer can benefit from genetic testing for all breast cancer genes," the article concludes.


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Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Tom Walsh, Jessica B. Mandell, Barbara M. Norquist, Silvia Casadei, Suleyman Gulsuner, Ming K. Lee, Mary-Claire King. Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women. JAMAOncology, 2017; DOI: 10.1001/jamaoncol.2017.1996

Cite This Page:

The JAMA Network Journals. "Genetic predisposition to breast cancer due to non-BRCA mutations in Ashkenazi Jewish women." ScienceDaily. ScienceDaily, 20 July 2017. <www.sciencedaily.com/releases/2017/07/170720142306.htm>.
The JAMA Network Journals. (2017, July 20). Genetic predisposition to breast cancer due to non-BRCA mutations in Ashkenazi Jewish women. ScienceDaily. Retrieved February 25, 2024 from www.sciencedaily.com/releases/2017/07/170720142306.htm
The JAMA Network Journals. "Genetic predisposition to breast cancer due to non-BRCA mutations in Ashkenazi Jewish women." ScienceDaily. www.sciencedaily.com/releases/2017/07/170720142306.htm (accessed February 25, 2024).

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