New! Sign up for our free email newsletter.
Science News
from research organizations

Antimalarial drugs could support existing cancer treatments in two-pronged attack

Chloroquine and hydroxychloroquine could make cancer treatments more effective

Date:
November 24, 2017
Source:
ecancermedicalscience
Summary:
Antimalarial drugs chloroquine and hydroxychloroquine could make tumour cells more sensitive to cancer treatment.
Share:
FULL STORY

Antimalarial drugs chloroquine and hydroxychloroquine could find another use as cancer treatments, according to a new clinical study published in ecancermedicalscience.

Researchers from the Repurposing Drugs in Oncology (ReDO) project, an international collaboration between the Anticancer Fund, Belgium, and USA-based GlobalCures, say there is evidence to include these drugs in further clinical investigations.

The authors are particularly excited about the potential for chloroquine and hydroxychloroquine as the evidence suggests they make tumour cells more sensitive to cancer treatment.

"What makes chloroquine and hydroxychloroquine so interesting is these multiple mechanisms of action," says Ciska Verbaanderd of the Anticancer Fund and the University of Leuven, Belgium, first author of the study."These antimalarial drugs act on both the level of cancer cells and the tumour microenvironment." Studying this has led to interesting scientific insights in tumour biology, such as the importance of autophagy, the tumour vasculature and the immune system."

"The results from thereview lead us to believe that these antimalarial drugs could offer significant clinical benefit for certain cancer patients, especially in combination with standard anticancer treatments.This should be confirmed by additional clinical results."

Vikas P. Sukhatme MD ScD, co-founder of GlobalCures and one of the authors of this review, added "We look forward with much anticipation to the results of the 30 or so ongoing clinical studies that use chloroquine or hydroxychloroquine for cancer treatment."

The researchers' hope is that with the publication of this study, increased awareness of the potential applications will bring these medications out of the medicine cabinet -- and into cancer care.

Previous papers from the ReDO project have explored how inexpensive, common drugs such as beta-blockers and anti-fungal remedies can be "repurposed" and used as part of cancer treatments.


Story Source:

Materials provided by ecancermedicalscience. Note: Content may be edited for style and length.


Journal Reference:

  1. Ciska Verbaanderd, Hannelore Maes, Marco B Schaaf, Vikas P Sukhatme, Pan Pantziarka, Vidula Sukhatme, Patrizia Agostinis, Gauthier Bouche. Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents. ecancermedicalscience, 2017; 11 DOI: 10.3332/ecancer.2017.781

Cite This Page:

ecancermedicalscience. "Antimalarial drugs could support existing cancer treatments in two-pronged attack." ScienceDaily. ScienceDaily, 24 November 2017. <www.sciencedaily.com/releases/2017/11/171124142850.htm>.
ecancermedicalscience. (2017, November 24). Antimalarial drugs could support existing cancer treatments in two-pronged attack. ScienceDaily. Retrieved June 17, 2024 from www.sciencedaily.com/releases/2017/11/171124142850.htm
ecancermedicalscience. "Antimalarial drugs could support existing cancer treatments in two-pronged attack." ScienceDaily. www.sciencedaily.com/releases/2017/11/171124142850.htm (accessed June 17, 2024).

Explore More

from ScienceDaily

RELATED STORIES