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Ketamine works for female rats, too

Research addresses critical gap in understanding disorders that disproportionately afflict females

Date:
February 26, 2018
Source:
Society for Neuroscience
Summary:
A first of its kind study in female rats finds that a single, low dose of ketamine promotes resilience to future adverse events as it does in male rats. New research addresses a critical gap in understanding and developing treatments for stress-related disorders, which disproportionately afflict females.
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A first of its kind study in female rats finds that a single, low dose of ketamine promotes resilience to future adverse events as it does in male rats. Published in eNeuro, the research addresses a critical gap in understanding and developing treatments for stress-related disorders, which disproportionately afflict females.

Ketamine has been used for decades as an anesthetic and recreational drug. However, ketamine given at a low-dose is currently being investigated for its rapid antidepressant effects that could benefit treatment-resistant patients. Although results from animal research are promising, most of these studies have used only males.

Dr. Samuel Dolzani and colleagues at the University of Colorado Boulder found that female rats treated with low-dose ketamine one week prior to tail shock stress prevented the typical stress-induced decrease in social exploration, reflecting reduced anxiety-like behavior. Strikingly, low-dose ketamine female rats exhibited social exploration levels similar to those of control female rats that did not experience tail shock stress. In collaboration with Dr. Yingxi Lin at the Massachusetts Institute of Technology, the researchers used a novel tagging system to show that neurons in the prefrontal cortex that were activated by low-dose ketamine were also turned on during the later stress experience. They went on to show that a neural circuit involving the prelimbic cortex and dorsal raphe nucleus was responsible for ketamine's resilience-promoting effects.


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Materials provided by Society for Neuroscience. Note: Content may be edited for style and length.


Journal Reference:

  1. S. D. Dolzani, M. V. Baratta, J. M. Moss, N. L. Leslie, S. G. Tilden, A. T. Sørensen, L. R. Watkins, Y. Lin and S. F. Maier. Inhibition of a descending prefrontal circuit prevents ketamine-induced stress resilience in females. eNeuro, 2018 DOI: 10.1523/ENEURO.0025-18.2018

Cite This Page:

Society for Neuroscience. "Ketamine works for female rats, too." ScienceDaily. ScienceDaily, 26 February 2018. <www.sciencedaily.com/releases/2018/02/180226131444.htm>.
Society for Neuroscience. (2018, February 26). Ketamine works for female rats, too. ScienceDaily. Retrieved May 19, 2024 from www.sciencedaily.com/releases/2018/02/180226131444.htm
Society for Neuroscience. "Ketamine works for female rats, too." ScienceDaily. www.sciencedaily.com/releases/2018/02/180226131444.htm (accessed May 19, 2024).

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