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Arthritis drugs potentially safe for expectant mothers

Pregnant mothers may use rheumatoid arthritis drugs without increased health risks to unborn baby

Date:
May 17, 2018
Source:
McGill University Health Centre
Summary:
A new study has revealed that pregnant women with rheumatoid arthritis (RA) may be able to use certain RA drugs without possible increased health risks to their unborn babies.
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A new study led by a team at the Research Institute of the MUHC (RI-MUHC) in Montreal has revealed that pregnant women with rheumatoid arthritis (RA) may be able to use certain RA drugs without possible increased health risks to their unborn babies. The research findings are published today in the journal Arthritis & Rheumatology.

Rheumatoid arthritis is a debilitating disease with physical, emotional, and economic consequences that afflicts about one per cent of the world's adult population. This autoimmune disease, which causes chronic inflammation of the joints and other areas of the body, affects two to three times more women than men and there is no existing cure.

Dr. Évelyne Vinet and her team from the Centre for Outcomes of Evaluative Research (CORE) of the RI-MUHC analyzed offspring exposed to tumour necrosis factors inhibitors (TNFs) -- an immunosuppressant RA drug commonly used to reduce inflammation and relieve pain.

They did not observe any marked excess risk of serious side effects when compared to unexposed children from mothers with RA and children from the general population. Their research showed that although TNFs cross the placenta, the drug may not increase immunosuppression nor compromise the child's ability to fight infections.

"Knowing there is not necessarily an association between infections and these RA drugs will be very reassuring to expectant mothers," says first author of the study Dr. Vinet, who is a scientist from the Infectious Diseases and Immunity in Global Health Program at the RI-MUHC and an assistant professor in the Department of Medicine and Division of Rheumatology at the Faculty of Medicine of McGill University. "It is important to highlight these findings so would-be mothers understand they can enjoy a normal pregnancy without being burdened by unnecessary stress."

Dr. Vinet's team studied nearly 3,000 children from mothers with RA (the largest cohort ever assembled) and a random selected group of nearly 15,000 children over the course of their first year of life. Within the RA group, 380 children were exposed to TNFs and 3.2 per cent presented serious infections. That number is just slightly above those with no TNFs (2 per cent) and the control group (1.9 percent).

"However, until further studies are conducted to address this issue," says Dr. Vinet, "it is important to follow current recommendations when treating women with rheumatoid arthritis during pregnancy."


Story Source:

Materials provided by McGill University Health Centre. Note: Content may be edited for style and length.


Journal Reference:

  1. Évelyne Vinet, Cristiano De Moura, Christian A Pineau, Michal Abrahamowicz, Jeffrey R. Curtis, Sasha Bernatsky. Serious infections in rheumatoid arthritis offspring exposed to tumour necrosis factor α inhibitors: cohort study. Arthritis & Rheumatology, 2018; DOI: 10.1002/art.40536

Cite This Page:

McGill University Health Centre. "Arthritis drugs potentially safe for expectant mothers." ScienceDaily. ScienceDaily, 17 May 2018. <www.sciencedaily.com/releases/2018/05/180517081822.htm>.
McGill University Health Centre. (2018, May 17). Arthritis drugs potentially safe for expectant mothers. ScienceDaily. Retrieved December 13, 2024 from www.sciencedaily.com/releases/2018/05/180517081822.htm
McGill University Health Centre. "Arthritis drugs potentially safe for expectant mothers." ScienceDaily. www.sciencedaily.com/releases/2018/05/180517081822.htm (accessed December 13, 2024).

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