Incorrectly assuming that women having a heart attack suffer different symptoms to men could lead to misdiagnosis, delayed treatment and less intensive medical interventions being offered. Previous BHF-funded research has shown the resulting differences in care for women were estimated to have contributed to at least 8,200 avoidable deaths in England and Wales in the last decade.

In this latest study, published in the Journal of the American Heart Association, researchers at the University of Edinburgh recorded the symptoms of people attending the Emergency Department (ED) at Edinburgh Royal Infirmary who had a blood test called a troponin test. This test is used when doctors suspect a person is having a heart attack, and measures a protein released by damaged heart cells during a heart attack.

Between 1st June 2013 and 3rd March 2017, doctors in the ED ordered the troponin test for 1,941 people. Of these people, 274 were diagnosed as having a type of heart attack known as an NSTEMI (90 women and 184 men). This is the most common type of heart attack, and occurs when the coronary artery is partially blocked.

Chest pain was the most common symptom for both men and women, with 93 per cent of both sexes reporting this symptom. A similar percentage of men and women reported pain that radiated to their left arm (48 percent of men and 49 per cent of women).

More women had pain that radiated to their jaw or back and women were also more likely to experience nausea in addition to chest pain (33 per cent vs 19 per cent).

Less typical symptoms, such as epigastric pain (heartburn), back pain, or pain that was burning, stabbing or similar to that of indigestion, were more common in men than women (41 per cent in men vs 23 per cent in women).

Previous research has suggested that women and men report different heart attack symptoms. However, the symptoms were often recorded after a heart attack diagnosis was confirmed, which may introduce bias. This study aimed to avoid this by asking an independent research nurse to interview and record the symptoms of all patients arriving at the ED with a possible heart attack before they were given a diagnosis.

The authors now say that further research is needed in larger and more diverse populations to confirm their findings.

Early diagnosis of a heart attack is essential for treatment and survival. BHF-funded research has previously shown that women having a heart attack are up to 50 per cent more likely than men to receive the wrong initial diagnosis and are less likely to get a pre-hospital ECG.

Amy Ferry, cardiology research nurse at the University of Edinburgh and first author, said:

"Our concern is that by incorrectly labelling women as having atypical symptoms, we may be encouraging doctors and nurses not to investigate or start treatment for coronary heart disease in women.

"Both men and women present with an array of symptoms, but our study shows that so-called typical symptoms in women should always be seen as a red flag for a potential heart attack."

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said:

"Heart attacks are often seen as a male health issue, but more women die from coronary heart disease than breast cancer in the UK. We need to change this harmful misconception because it is leading to avoidable suffering and loss of life.

"In the UK, three women die of coronary heart disease every hour, many of them due to a heart attack. We know that women tend to wait longer before calling 999 after first experiencing heart attack symptoms. But that delay can dramatically reduce your chance of survival."

The BHF is calling for everyone to be more aware of the most common symptoms of a heart attack:

• pain or discomfort in your chest that occurs suddenly and doesn't go away
• pain that may spread to your left or right arm, or to your neck, jaw, back or stomach. For some people the pain or tightness is severe, while other people just feel uncomfortable
• feeling sick, sweaty, light-headed or short of breath.

A heart attack is a medical emergency and can be life threatening. People experiencing any of these symptoms should phone 999 immediately for an ambulance, regardless of their sex.

Story Source:

Materials provided by British Heart Foundation. Original written by Jennifer Mitchell. Note: Content may be edited for style and length.

Journal Reference:

1. Amy V. Ferry, Atul Anand, Fiona E. Strachan, Leanne Mooney, Stacey D. Stewart, Lucy Marshall, Andrew R. Chapman, Kuan Ken Lee, Simon Jones, Katherine Orme, Anoop S. V. Shah, Nicholas L. Mills. Presenting Symptoms in Men and Women Diagnosed With Myocardial Infarction Using Sex‐Specific Criteria. Journal of the American Heart Association, 2019; 8 (17) DOI: 10.1161/JAHA.119.012307