Featured Research

from universities, journals, and other organizations

Genetic Code 2.0: Novel artificial proteins for industry and science

Date:
July 1, 2010
Source:
Max-Planck-Gesellschaft
Summary:
The creation of synthetic proteins plays an important role for economy and science. By the integration of artificial amino acids in proteins (genetic code engineering), their already existing qualities can be systematically improved, allowing new biological features to arise. Now, scientists in Germany have succeeded in taking another important step in this research area: For the first time, they were able to integrate three different synthetic amino acids into one protein in a single experiment.

For the first time, three amino acids of one protein could be changed at the same time in a single experiment.
Credit: Nediljko Budisa / MPI of Biochemistry

The creation of synthetic proteins plays an important role for economy and science. By the integration of artificial amino acids in proteins (genetic code engineering), their already existing qualities can be systematically improved, allowing new biological features to arise. Now, scientists at the Max Planck Institute of Biochemistry (MPIB) in Martinsried near Munich, Germany, have succeeded in taking another important step in this research area: For the first time, they were able to integrate three different synthetic amino acids into one protein in a single experiment.

The research is published in the journal Angewandte Chemie (June 24, 2010).

Proteins are the main actors in our body: They transport substances, convey messages or carry out vital processes in their role as molecular machines. The "helmsmen of the cell" are composed of amino acids, whose sequence is already defined by the heritable information in every living being. The translation of this information during the production of proteins (protein synthesis) is determined by the genetic code. 20 amino acids form the standard set of which proteins are built. In natural conditions, however, several hundred amino acids can be found and, of course, new amino acids can also be produced in the laboratory. With regard to their properties, they differ from the 20 standard amino acids, because of which, by their integration in proteins, specific structural and biological characteristics of proteins can be systematically changed. So far, only one type of synthetic amino acid could be inserted into a protein during a single experiment in a residue-specific manner; thus, only one property of a protein could be modified at once.

Nediljko Budisa, head of the research group Molecular Biotechnology at the MPIB, has now made important methodical progress in the area of genetic code engineering. The scientists were able to substitute three different natural amino acids by synthetic ones at the same time in a single experiment. The biochemist is pleased: "The research area of genetic code engineering and code extension has with this result reached a new development phase."

Budisa's method could be of great importance, particularly for the industry and economy, because the production of artificial proteins by genetic code engineering in his view demonstrates a solid basis for the development of new technologies. "During integration, synthetic amino acids confer their characteristics to proteins. Thus, the development will allow the synthesis of totally new classes of products, whose chemical synthesis has not been possible so far by conventional protein engineering using only the 20 standard amino acids," explains Budisa regarding to future prospects. "Thanks to our method, in the future it will be possible to tailor industrial relevant proteins with novel properties: for example proteins containing medical components."


Story Source:

The above story is based on materials provided by Max-Planck-Gesellschaft. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sandra Lepthien, Lars Merkel, Nediljko Budisa. In Vivo Double and Triple Labeling of Proteins Using Synthetic Amino Acids. Angewandte Chemie International Edition, 2010; DOI: 10.1002/anie.201000439

Cite This Page:

Max-Planck-Gesellschaft. "Genetic Code 2.0: Novel artificial proteins for industry and science." ScienceDaily. ScienceDaily, 1 July 2010. <www.sciencedaily.com/releases/2010/06/100630110908.htm>.
Max-Planck-Gesellschaft. (2010, July 1). Genetic Code 2.0: Novel artificial proteins for industry and science. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2010/06/100630110908.htm
Max-Planck-Gesellschaft. "Genetic Code 2.0: Novel artificial proteins for industry and science." ScienceDaily. www.sciencedaily.com/releases/2010/06/100630110908.htm (accessed April 21, 2014).

Share This



More Plants & Animals News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mich. Boy Unearths 10,000-Year-Old Mastodon Tooth

Mich. Boy Unearths 10,000-Year-Old Mastodon Tooth

Newsy (Apr. 20, 2014) A 9-year-old Michigan boy was exploring a creek when he came across a 10,000-year-old tooth from a prehistoric mastodon. Video provided by Newsy
Powered by NewsLook.com
Vermont Goat Meat Gives Refugees Taste of Home

Vermont Goat Meat Gives Refugees Taste of Home

AP (Apr. 18, 2014) Dairy farmers and ethnic groups in Vermont are both benefiting from a unique collaborative effort that's feeding a growing need for fresh and affordable goat meat. (April 18) Video provided by AP
Powered by NewsLook.com
Man Claims He Found Loch Ness Monster With... Apple Maps?

Man Claims He Found Loch Ness Monster With... Apple Maps?

Newsy (Apr. 18, 2014) Andy Dixon showed the Daily Mail a screenshot of what he believes to be the mythical beast swimming just below the lake's surface. Video provided by Newsy
Powered by NewsLook.com
First Ever 'Female Penis' Discovered In Animal Kingdom

First Ever 'Female Penis' Discovered In Animal Kingdom

Newsy (Apr. 18, 2014) Not only are these newly discovered bugs' sex organs reversed, but they also mate for up to 70 hours. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins