Featured Research

from universities, journals, and other organizations

New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada

Date:
May 30, 2011
Source:
Canadian Medical Association Journal
Summary:
An enzyme associated with extensive antibiotic resistance called New Delhi metallo--lactamase-1 (NDM-1), endemic in India and Pakistan and spreading worldwide, has been found in two people in the Toronto area, one of whom acquired it in Canada, states a new case report. The report outlines challenges and approaches to managing and identifying this pathogen, which is highly resistant to treatment.

An enzyme associated with extensive antibiotic resistance called New Delhi metallo--lactamase-1 (NDM-1), endemic in India and Pakistan and spreading worldwide, has been found in two people in the Toronto area, one of whom acquired it in Canada, states a case report in CMAJ (Canadian Medical Association Journal). The report outlines challenges and approaches to managing and identifying this pathogen, which is highly resistant to treatment.

NDM-1 has spread because of worldwide travel, medical tourism and its ability to transfer between bacteria.

In one of the cases in this report, the patient had not travelled outside southwestern Ontario in over a decade, and no source could be identified for the organism. In the other case, the patient had been hospitalized in India for a medical procedure and acquired the organism there.

"These two scenarios show that local acquisition of an organism producing NDM-1 has already occurred in Ontario, Canada, that blaNDM-1 has been found in bacterial species other than [Escherichia coli] and [Klebsiella pneumoniae], that treatment options are limited for infections with NDM-1-producing organisms, and that the detection of NDM-1-producing organisms by a laboratory can be difficult," writes Dr. Susan Poutanen, Mount Sinai Hospital and University Health Network, with coauthors.

In the case of the patient who had not travelled, the authors note: "To the best of our knowledge, this is the first reported instance in which an NDM-1-producing organism was locally acquired in Canada."

In cases where patients are infected with NDM-1, extensive infection control precautions must be taken, including isolation in single rooms and enhanced cleaning.

"European guidelines recommend even more precautionary approaches to protecting patients admitted to hospital and suggest that all hospitals should have preparedness plans in place," state the authors.

Laboratory detection of the pathogen is also difficult, and labs should adopt different screening procedures.


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Julianne V. Kus, Manal Tadros, Andrew Simor, Donald E. Low, Allison J. McGeer, Barbara M. Willey, Cindy Larocque, Karen Pike, Iris-Ann Edwards, Helen Dedier, Roberto Melano, David A. Boyd, Michael R. Mulvey, Lisa Louie, Christopher Okeahialam, Mark Bayley, Cynthia Whitehead, Denyse Richardson, Lesley Carr, Fatema Jinnah and Susan M. Poutanen. New Delhi metallo--lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. Canadian Medical Association Journal, May 30, 2011 DOI: 10.1503/cmaj.110477

Cite This Page:

Canadian Medical Association Journal. "New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada." ScienceDaily. ScienceDaily, 30 May 2011. <www.sciencedaily.com/releases/2011/05/110530152338.htm>.
Canadian Medical Association Journal. (2011, May 30). New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/05/110530152338.htm
Canadian Medical Association Journal. "New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada." ScienceDaily. www.sciencedaily.com/releases/2011/05/110530152338.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins