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Revolutionary method of making RNAs

Date:
May 4, 2015
Source:
University of Texas Health Science Center at San Antonio
Summary:
Scientists -- and ultimately patients -- could benefit from a new approach to making ribonucleic acids.
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A biochemist from The University of Texas Health Science Center at San Antonio is a co-author on a paper in Nature that describes a new, more efficient method of making ribonucleic acids (RNAs).

RNAs are molecules that can be used to make therapeutics, sensors and diagnostics, for which there is a growing market, said Rui Sousa, Ph.D., professor of biochemistry in the School of Medicine at the Health Science Center. He is a co-author on the paper with colleagues from the National Institutes of Health, the University of Colorado and Leidos Biomedical Research Inc. in Frederick, Md.

"This new technique allows a researcher to make RNA molecules that are chemically diverse," Dr. Sousa said. "This is desirable for studies of RNA structure and function, and for design of applications that could be used to diagnose and treat disease."

Deoxyribonucleic acid (DNA), a double-stranded molecule, is the genetic blueprint contained in all cells. The genetic information of DNA is copied into molecules called messenger RNAs, which are basically the manufacturing instructions for proteins. Different types of RNAs perform different functions, such as silencing a gene or regulating a plethora of processes in cells.

Until now, researchers' ability to fine-tune RNAs to develop diagnostics and therapeutics has been limited by existing technology. The new method described by Dr. Sousa and his colleagues in Nature, which includes robotics, will speed up research exponentially, he said.


Story Source:

Materials provided by University of Texas Health Science Center at San Antonio. Note: Content may be edited for style and length.


Journal Reference:

  1. Yu Liu, Erik Holmstrom, Jinwei Zhang, Ping Yu, Jinbu Wang, Marzena A. Dyba, De Chen, Jinfa Ying, Stephen Lockett, David J. Nesbitt, Adrian R. Ferré-D’Amaré, Rui Sousa, Jason R. Stagno & Yun-Xing Wang. Synthesis and applications of RNAs with position-selective labelling and mosaic composition. Nature, 2015 DOI: 10.1038/nature14352

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University of Texas Health Science Center at San Antonio. "Revolutionary method of making RNAs." ScienceDaily. ScienceDaily, 4 May 2015. <www.sciencedaily.com/releases/2015/05/150504121041.htm>.
University of Texas Health Science Center at San Antonio. (2015, May 4). Revolutionary method of making RNAs. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/05/150504121041.htm
University of Texas Health Science Center at San Antonio. "Revolutionary method of making RNAs." ScienceDaily. www.sciencedaily.com/releases/2015/05/150504121041.htm (accessed May 23, 2017).

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