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Scientists find potential target for dry age-related macular degeneration

Date:
November 3, 2015
Source:
Association for Research in Vision and Ophthalmology (ARVO)
Summary:
Scientists have good news for patients who suffer from currently untreatable dry age-related macular degeneration (dry AMD). In a new study, researchers identified a potential target for future therapies to slow the progression of the blinding condition. The findings indicate that treatments currently used for other conditions could also work for dry AMD.
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Scientists have good news for patients who suffer from currently untreatable dry age-related macular degeneration (dry AMD). In a new study, researchers identified a potential target for future therapies to slow the progression of the blinding condition. Published in Investigative Ophthalmology & Visual Science (IOVS), the findings indicate that treatments currently used for other conditions could also work for dry AMD.

The paper, "Protective Effects of Anti-Placental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice," brings to light the effect of a known protein, placental growth factor (PlGF), on the development of dry AMD. PlGF had previously been implicated in the progression of a related disease known as wet AMD.

"Currently, blocking PlGF in wet AMD has a therapeutic effect," says author Hideaki Hara, PhD, of Gifu Pharmaceutical University, Department of Biofunctional Evaluation. "In our study, we wanted to learn if PlGF could be a useful therapeutic target for dry AMD."

Earlier in vitro studies by the authors showed that injecting PlGF into retinal cells -- the cells at the back of the eye responsible for sight -- reduced light-induced damage. In this work, the authors evaluated how mice retina responded to injection of PlGF before and after exposure to intense light, a procedure that produces dry AMD like conditions. Surprisingly, the new in vivo mouse studies contradicted the previous results.

"In the present study, we thought that treatment with PlGF would show a protective effect against light-induced retinal degeneration," explains Hara. "Instead, PlGF aggravated the degeneration."

With PlGF seeming to make things worse, the authors then tested anti- PlGF, an antibody that binds PlGF and prevents it from acting. "Anti- PlGF antibody treatment protected against retinal degeneration induced by light exposure. Therefore, our results indicate that an anti-PlGF antibody can become a therapeutic agent in minimizing light-induced degeneration," says Hara.

Fortunately, an existing treatment for wet AMD known as aflibercept already acts as an anti-PlGF antibody. Hara and his team "think there is a very great likelihood that aflibercept shows efficacy in dry AMD." Using an existing drug in clinical trials could shave years off the time needed to determine if an anti-PlGF treatment could address dry AMD, an encouraging prospect for those suffering from the slow, currently untreatable vision loss resulting from the condition.


Story Source:

Materials provided by Association for Research in Vision and Ophthalmology (ARVO). Note: Content may be edited for style and length.


Journal Reference:

  1. Hiroshi Izawa, Yuki Inoue, Yuta Ohno, Kazuki Ojino, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara. Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice. Investigative Opthalmology & Visual Science, 2015; 56 (11): 6914 DOI: 10.1167/iovs.15-16748

Cite This Page:

Association for Research in Vision and Ophthalmology (ARVO). "Scientists find potential target for dry age-related macular degeneration." ScienceDaily. ScienceDaily, 3 November 2015. <www.sciencedaily.com/releases/2015/11/151103163556.htm>.
Association for Research in Vision and Ophthalmology (ARVO). (2015, November 3). Scientists find potential target for dry age-related macular degeneration. ScienceDaily. Retrieved May 27, 2017 from www.sciencedaily.com/releases/2015/11/151103163556.htm
Association for Research in Vision and Ophthalmology (ARVO). "Scientists find potential target for dry age-related macular degeneration." ScienceDaily. www.sciencedaily.com/releases/2015/11/151103163556.htm (accessed May 27, 2017).

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