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Experimental drug more effective in treating rare kidney disease

Date:
October 25, 2018
Source:
NYU Langone Health / NYU School of Medicine
Summary:
New study finds that experimental drug sparsentan is an effective treatment for the rare kidney disease focal segmental glomerulosclerosis, which currently has no FDA-approved therapies.
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FULL STORY

An experimental drug is more than twice as effective as the standard treatment at reducing a key measure of severity in a rare kidney disease. This is the finding of a phase II clinical trial published online October 25th in the Journal of the American Society of Nephrology.

The new study found that patients with focal segmental glomerulosclerosis (FSGS) taking the drug sparsentan saw a 45 percent reduction in proteinuria -- an excess of protein in the urine that suggests poor kidney health. This compared to a 19 percent reduction in the group receiving the typically prescribed irbesartan.

"This is the first large-scale clinical trial of a treatment designed specifically to target FSGS, a rare disorder estimated to affect up to 40,000 people in the United States, and for which there are currently no approved therapies," says principal investigator and lead study author Howard Trachtman, MD, professor in the Department of Pediatrics at NYU School of Medicine and director of the division of pediatric nephrology at Hassenfeld Children's Hospital at NYU Langone. Nearly half of affected patients will progress to end-stage kidney disease, he says.

"Not only could sparsentan become part of the standard of care for patients with FSGS, but there are potential implications for any patient with kidney disease characterized by proteinuria -- including the more common IgA nephropathy which affects hundreds of thousands of people worldwide," says Dr. Trachtman.

Nephrologists use proteinuria as a measure, or marker, of the health of FSGS patients. When healthy, the kidneys filter blood, divert waste into urine, and return useful proteins to the bloodstream. FSGS, along with more common kidney diseases, damage the kidney's filtering units, with proteins passing through, and entering the urine to cause scarring in kidney tubules.

With no approved treatments for FSGS, the field has sought to apply to it medications developed to treat other diseases, says Trachtman, including angiotensin II receptor blockers (ARBs) like irbesartan. Initially developed to treat high blood pressure, ARBs are currently used in lieu of an approved FSGS therapy. These drugs act by lowering the blood pressure within the filtering units of the kidney and reducing kidney scarring.

New Approach

For the new study, researchers enrolled 109 patients with FSGS, ages 8-75 in the US and 18-75 in Europe, in a randomized, double-blind, active-controlled trial (DUET) across 44 sites to assess the efficacy and safety of sparsentan. Participants were assigned either escalating doses of sparsentan (200, 400, or 800 mg per day) or irbesartan in 300 mg per day doses over eight weeks. After completing the double-blind eight-week treatment period, patients were able to continue to receive sparsentan in an open-label treatment period.

The study medication, sparsentan, works both as an angiotensin II receptor blocker like irbesartan, and as a blocker of the action of a second protein, endothelin receptor type A (ETA). The study authors had hypothesized that the two actions would together limit the production of molecules that lead to kidney scarring more than irbesartan's single mechanism.

Sparsentan was indeed found to be more effective, and also to have very few serious side effects, with the most common -- low blood pressure, dizziness, and swelling -- similar in both groups. The research team also found that combining effects in a single molecule increased patients' likelihood of taking their treatment because it reduced the number of pills.

Further study is needed to determine the long-term effects of sparsentan on preservation of kidney function, say the authors. In addition to the open-label treatment period of DUET, a phase III clinical trial (DUPLEX) is actively enrolling patients to determine if sparsentan brings about a sustained reduction of proteinuria.

"The prevalence of FSGS is on the rise, and this combined therapy could offer new hope for patients with this rare kidney disorder who currently face a progressive decline, a high chance of end-stage kidney disease, dialysis or transplantation," says Dr. Trachtman.

In addition to Trachtman, study coauthors include Olga Zhdanova, MD, in the Department of Medicine, Division of Nephrology at NYU School of Medicine; Peter Nelson, MD; Sharon Adler, MD; Kirk N. Campbell, MD; Abanti Chaudhuri, MD; Vimal K. Derebail, MD; Giovanni Gambaro, MD, PhD; Loreto Gesualdo, MD; Debbie S. Gipson, MD; Jonathan Hogan, MD; Kenneth Lieberman, MD; Brad Marder, MD; Kevin E. Meyers, MD; Esmat Mustafa, MD; Jai Radhakrishnan, MD; Tarak Srivastava, MD; Miganush Stepanians, PhD; Vladimir Tesar, MD; and Radko Komers, MD, PhD, on behalf of the DUET study group.

Sparsentan is manufactured by Retrophin, Inc., the biopharmaceutical company that funded the current clinical trial. Dr. Trachtman served as an unpaid consultant for Retrophin, has reported receiving consultancy fees from Kaneka Inc, Otsuka, and ChemoCentryx and was a consultant in the past to Genzyme and Optherion. All relationships are being managed in accordance with the policies of NYU School of Medicine.


Story Source:

Materials provided by NYU Langone Health / NYU School of Medicine. Note: Content may be edited for style and length.


Journal Reference:

  1. Howard Trachtman, Peter Nelson, Sharon Adler, Kirk N. Campbell, Abanti Chaudhuri, Vimal Kumar Derebail, Giovanni Gambaro, Loreto Gesualdo, Debbie S. Gipson, Jonathan Hogan, Kenneth Lieberman, Brad Marder, Kevin Edward Meyers, Esmat Mustafa, Jai Radhakrishnan, Tarak Srivastava, Miganush Stepanians, Vladimír Tesar, Olga Zhdanova, Radko Komers. DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS. Journal of the American Society of Nephrology, 2018; ASN.2018010091 DOI: 10.1681/ASN.2018010091

Cite This Page:

NYU Langone Health / NYU School of Medicine. "Experimental drug more effective in treating rare kidney disease." ScienceDaily. ScienceDaily, 25 October 2018. <www.sciencedaily.com/releases/2018/10/181025141942.htm>.
NYU Langone Health / NYU School of Medicine. (2018, October 25). Experimental drug more effective in treating rare kidney disease. ScienceDaily. Retrieved October 6, 2024 from www.sciencedaily.com/releases/2018/10/181025141942.htm
NYU Langone Health / NYU School of Medicine. "Experimental drug more effective in treating rare kidney disease." ScienceDaily. www.sciencedaily.com/releases/2018/10/181025141942.htm (accessed October 6, 2024).

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