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Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer

January 17, 2020
La Trobe University
Activation of the BMP4 signalling pathway presents a new therapeutic strategy to combat metastatic breast cancer, a disease that has shown no reduction in patient mortality over the past 20 years.

Metastasis, the spread of tumour cells to distant sites, is the major cause of death for people impacted by cancer. With no therapeutic cure available, it is clear that new treatments are needed urgently.

In a study published today in the international journal, Cancer Research a journal of the American Association for Cancer Research, investigators at the Olivia Newton-John Cancer Research Institute (the La Trobe University School of Cancer Medicine) have shown that when the protein bone morphogenetic protein-4 (BMP4) is switched off, breast cancer can become more aggressive. BMP4 is active during fetal development and is maintained during adulthood in some healthy organs, including the breast.

In this study, led by investigators Dr Bedrich Eckhardt (a Susan G Komen Postdoctoral Fellow) and Prof Robin Anderson (Head of the Translational Breast Cancer Program), it was hypothesised that restoring BMP4 activity would block the ability of breast tumours to metastasise.

"At its core, this study has demonstrated that high levels of the BMP4 protein in breast cancer patients is associated with better outcome, linked to a reduction in metastatic breast cancer," said Prof Anderson. "This is an exciting finding as there has been no reduction in the rates of mortality for people with metastatic breast cancer for over 20 years."

This translational research study revealed that levels of the BMP4 protein are often reduced in late stage breast cancer. But when BMP4 levels were restored in preclinical models of metastatic breast cancer, it could block distant metastasis in multiple organs including the lung and bone. These findings have been achieved through collaboration with researchers at Peter MacCallum Cancer Centre, Fiona Stanley Hospital (University of Western Australia) and MD Anderson Cancer Center (University of Texas, USA).

"As part of the study, we were able to demonstrate how BMP4 activates cellular pathways to block the ability of tumour cells to metastasise," Dr Eckhardt explains, "and importantly show that key proteins induced by BMP4 are critical to block metastasis by reducing the number of circulating tumour cells within the blood."

While the ultimate aim is to bring a new therapy into the clinic through clinical trials, the next phase of research will focus on finding a compound that mimics the anti-metastatic actions of BMP4.

"A current challenge is that BMP4 protein has an active half-life of only 15 minutes or less in the body after administration, so it is not a practical long-term therapy," said Prof Anderson. "We will now focus on finding a more therapeutically viable way of mimicking the action of BMP4 in vivo as a new lead therapy for patients with metastatic breast cancer," said Prof Anderson.

Story Source:

Materials provided by La Trobe University. Note: Content may be edited for style and length.

Journal Reference:

  1. Bedrich L. Eckhardt, Yuan Cao, Andrew D Redfern, Lap Hing Chi, Allan D Burrows, Suraya Roslan, Erica K. Sloan, Belinda S. Parker, Sherene Loi, Naoto T. Ueno, Peter K. H. Lau, Bruce Latham, Robin L Anderson. Activation of canonical BMP4-SMAD7 signaling suppresses breast cancer metastasis. Cancer Research, 2020; canres.0743.2019 DOI: 10.1158/0008-5472.CAN-19-0743

Cite This Page:

La Trobe University. "Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer." ScienceDaily. ScienceDaily, 17 January 2020. <>.
La Trobe University. (2020, January 17). Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer. ScienceDaily. Retrieved November 29, 2023 from
La Trobe University. "Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer." ScienceDaily. (accessed November 29, 2023).

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