Featured Research

from universities, journals, and other organizations

First French bulldog with sex reversal identified in Spain

Date:
March 23, 2011
Source:
FECYT - Spanish Foundation for Science and Technology
Summary:
Tana, a female French bulldog, was brought to a veterinary center for her first vaccination. Specialists there were alerted by the size of her clitoris, which was "larger than normal", and they started to carry out tests. These revealed the first ever genetic alteration ever detected in the reproductive system of this breed -- the female puppy had cryptorchid testicles (outside the scrotum).

To prevent Tana from suffering any medical complications, the best option was felt to be surgical sterilization.
Credit: Marcos Campos.

Tana, a female French bulldog, was brought to a veterinary centre for her first vaccination. Specialists there were alerted by the size of her clitoris, which was "larger than normal," and they started to carry out tests. These revealed the first ever genetic alteration ever detected in the reproductive system of this breed -- the female puppy had cryptorchid testicles (outside the scrotum).

Genetic alteration of the reproductive system or sexual reversal "has been described in many species, such as goats, pigs, horses and even human beings," Marcos Campos, lead author of the study and also a researcher at the CEU-Cardenal Herrera University and director of the Reprovalcan assisted reproduction centre for small animals, said.

The puppy Tana, which was three months old when brought for her first consultation, presented symptoms compatible with having a genetic alteration of the reproductive system -- she had a large clitoris. "She was a chromosomally XX female but with masculine gonads (cryptorchid testicles) due to the presence of other genes that determined the formation of testicles in the absence of the genes present on the Y chromosome," explains Campos.

This alteration, which has also been described in another 18 breeds of dog around the world, is "uncommon but it can occur." Sex reversal causes sterility and, over the long term, may predispose the animal to pathologies such as infections or tumours of the gonads, "since this is not a normal genital," the veterinarian explains.

The study, which has been published in Reproduction in Domestic Animals, showed that the urethra ended in the bladder, and the clitoris, which was 0.8 centimetres long, contained a penis bone, which predisposed it to urinary infections that would likely cause the dog to be infertile.

Canine hermaphroditism with a happy ending

The puppy, which is the first documented case anywhere in the world of a French bulldog with this alteration, had a low level of masculinisation, since despite the size of the clitoris, the vulva was normal.

To prevent Tana from suffering any medical complications, the best option was felt to be surgical sterilisation, during which her genitals were completely removed and later sent to a histopathology laboratory. "The puppy is now in perfect health," says Campos.

The veterinarians suggest that the parents of hermaphrodite puppies should be withdrawn from breeding programmes, because "it is likely that at least half of their litters will be carriers." The siblings of affected puppies should not be allowed to breed either until the mutant genes have been identified, which would make it possible to eliminate the carriers.

However, there are still no data available about the affected dogs belonging to this particular breed, which would enable the heredity model to be identified. Genetic modelling from other breeds shows that this is a autosomal recessive alteration (the animal only needs to receive the abnormal gene from one of its parents in order to inherit the sex reversal).


Story Source:

The above story is based on materials provided by FECYT - Spanish Foundation for Science and Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Campos, M.; Moreno-Manzano, V.; García-Roselló, M.; García-Roselló, E. SRY-Negative XX Sex Reversal in a French Bulldog. Reproduction in Domestic Animals, 46(1): 185-188, February 2011

Cite This Page:

FECYT - Spanish Foundation for Science and Technology. "First French bulldog with sex reversal identified in Spain." ScienceDaily. ScienceDaily, 23 March 2011. <www.sciencedaily.com/releases/2011/03/110323140245.htm>.
FECYT - Spanish Foundation for Science and Technology. (2011, March 23). First French bulldog with sex reversal identified in Spain. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/03/110323140245.htm
FECYT - Spanish Foundation for Science and Technology. "First French bulldog with sex reversal identified in Spain." ScienceDaily. www.sciencedaily.com/releases/2011/03/110323140245.htm (accessed July 31, 2014).

Share This




More Plants & Animals News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Visitors Feel Part of the Pack at Wolf Preserve

Visitors Feel Part of the Pack at Wolf Preserve

AP (July 31, 2014) — Seacrest Wolf Preserve on the northern Florida panhandle allows more than 10,000 visitors each year to get up close and personal with Arctic and British Columbian Wolves. (July 31) Video provided by AP
Powered by NewsLook.com
Florida Panther Rebound Upsets Ranchers

Florida Panther Rebound Upsets Ranchers

AP (July 31, 2014) — With Florida's panther population rebounding, some ranchers complain the protected predators are once again killing their calves. (July 31) Video provided by AP
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Raw: Thousands Flocking to German Crop Circle

Raw: Thousands Flocking to German Crop Circle

AP (July 30, 2014) — Thousands of people are trekking to a Bavarian farmer's field to check out a mysterious set of crop circles. (July 30) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins