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New links between obesity, cardiovascular disease found

Date:
January 22, 2015
Source:
Boston University Medical Center
Summary:
Novel methods have been applied in a recent study to detect binding of fatty acids to CD36 and their effect on internalization of oxidized LDL.
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In a new study published in the Journal of Biological Chemistry, a research group led by James A. Hamilton, PhD, professor of Physiology, Biophysics and Radiology at Boston University School of Medicine, applied novel methods to detect binding of fatty acids to CD36 and their effect on internalization of oxidized LDL. Although other research groups have characterized a fatty acid binding site on CD36 and postulated CD36 to be a gatekeeper for fatty acid entry into cells, the Hamilton lab previously found that CD36 did not increase fatty acid translocation across the plasma membrane.

In the current study all of the common dietary fatty acid types (saturated, unsaturated, trans and polyunsaturated) were shown by a new assay to bind to CD36 at levels greater than expected for a single binding site characterized in previous studies. In cells with CD36 present in the plasma membrane, all of the fatty acids also enhanced oxidized LDL uptake, except for the fish oil fatty acid DHA. This current study adds to the possible mechanisms for fish oil benefits that are now widely recognized.

"Since obesity and type 2 diabetes are characterized by high plasma levels of fatty acids, the demonstrated enhancement of oxLDL uptake by increases in common dietary fatty acids may contribute to the pathophysiology of these diseases. Furthermore, our new results provided a link between fatty acids, CD36, and atherosclerosis and new drugs can be designed that target the exact mechanism more precisely." added Hamilton.


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Materials provided by Boston University Medical Center. Note: Content may be edited for style and length.


Journal Reference:

  1. A. G. Jay, A. N. Chen, M. A. Paz, J. P. Hung, J. A. Hamilton. CD36 binds oxidized LDL in a mechanism dependent upon fatty acid binding. Journal of Biological Chemistry, 2015; DOI: 10.1074/jbc.M114.627026

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Boston University Medical Center. "New links between obesity, cardiovascular disease found." ScienceDaily. ScienceDaily, 22 January 2015. <www.sciencedaily.com/releases/2015/01/150122133217.htm>.
Boston University Medical Center. (2015, January 22). New links between obesity, cardiovascular disease found. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/01/150122133217.htm
Boston University Medical Center. "New links between obesity, cardiovascular disease found." ScienceDaily. www.sciencedaily.com/releases/2015/01/150122133217.htm (accessed May 23, 2017).

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