Prions News
September 26, 2016
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September 26, 2016

Prion Trials and Tribulations: Finding the Right Tools and Experimental Models

July 2, 2015 — Prions are fascinating, enigmatic, and might teach us not only about rare prion diseases like Creutzfeld-Jakob disease, mad cow disease, or scrapie, but also about other more common neurodgenerative ... read more

Blood Test to Screen for Fatal Variant Creutzfeldt-Jakob Disease

Mar. 4, 2014 — A blood test accurately screened for infection with the agent responsible for variant Creutzfeldt-Jakob disease (vCJD), a fatal neurological disease. vCJD is a fatal degenerative brain disorder ... read more

Connection Found in Pathogenesis of Neurological Diseases, HIV

Feb. 4, 2014 — A new study published shows similarities in the pathogenesis of prion disease -- misfolded proteins that can lead to neurological diseases -- and the HIV ... read more

The Shape of Infectious Prions

Jan. 24, 2014 — Prions are unique infective agents -- unlike viruses, bacteria, fungi and other parasites, prions do not contain either DNA or RNA. Despite their seemingly simple structure, they can propagate their ... read more

Breakthrough in Understanding Secret Life of Prion Molecules

Jan. 16, 2014 — New research has uncovered a quality control mechanism in brain cells that may help keep deadly neurological diseases in check for months or ... read more

Targeted Culling of Deer Controls Disease With Little Effect on Hunting

Oct. 21, 2013 — Chronic wasting disease, the deer-equivalent of mad cow disease, has crept across the US landscape from west to east, and was first detected in the Midwest in 2002. Little is known about its ... read more

New Models Advance the Study of Deadly Human Prion Diseases

Aug. 19, 2013 — By directly altering the gene coding for the prion protein (PrP), researchers have created mouse models of two neurodegenerative prion diseases, each of which manifests in different regions of the ... read more

Flexible Tail of the Prion Protein Poisons Brain Cells

July 31, 2013 — Prion proteins are the infectious pathogens that cause Mad Cow Disease and Creutzfeldt-Jakob disease. They occur when a normal prion protein becomes deformed and clumped. The naturally occurring ... read more

The Ribosome: New Target for Antiprion Medicines

July 2, 2013 — The key to treating neurodegenerative prion diseases such as mad cow disease and Creutzfeldt-Jakob disease may lie in the ribosome, the protein synthesis machinery of the cell. Prion diseases are ... read more

Potential Therapy for Human Prion Disease

Apr. 3, 2013 — Scientists have for the first time identified a pair of drugs already approved for human use that show anti-prion activity and, for one of them, great promise in treating rare and universally fatal ... read more

Protective Prion Keeps Yeast Cells from Going It Alone

Mar. 28, 2013 — A team of scientists has added markedly to the job description of prions as agents of change, identifying a prion capable of triggering a transition in yeast from its conventional single-celled form ... read more

Normal Prion Protein Regulates Iron Metabolism

Mar. 13, 2013 — An iron imbalance caused by prion proteins collecting in the brain is a likely cause of cell death in Creutzfeldt-Jakob disease, researchers have found. The breakthrough follows discoveries that ... read more

Discovery May Explain How Prion Diseases Spread Between Different Types of Animals

Mar. 11, 2013 — Medical researchers have made a discovery that may explain how prion diseases, like chronic wasting disease and mad cow disease, adapt in order to spread between various types of ... read more

Brain Inflammation Likely Key Initiator to Prion and Parkinson's Disease

Nov. 29, 2012 — Researchers have shown that neuro-inflammation plays a crucial role in initiating prion ... read more

Crows Don't Digest Prions, May Transport Them to Other Locations

Oct. 17, 2012 — Crows fed on prion-infected brains from mice can transmit these infectious agents in their feces and may play a role in the geographic spread of diseases caused by prions, such as chronic wasting ... read more

'Mad Cow' Blood Test Now on the Horizon

Sep. 12, 2012 — A simple blood test for Creutzfeldt-Jakob Disease and Mad Cow disease is a step closer, following a breakthrough by medical researchers in ... read more

Copper Facilitates Prion Disease, Scientists Show

Aug. 9, 2012 — Many of us are familiar with prion disease from its most startling and unusual incarnations —- the outbreaks of “mad cow” disease (bovine spongiform encephalopathy) that created a crisis in the ... read more

New Compounds Inhibit Prion Infection

July 23, 2012 — Researchers have identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals. ... read more

Prions in the Brain Eliminated by Homing Molecules

Apr. 24, 2012 — Toxic prions in the brain can be detected with self-illuminating polymers. The originators, at Linköping University in Sweden, has now shown that the same molecules can also render the prions ... read more

New Yeast Prion Helps Cells Survive

Apr. 23, 2012 — One of the greatest mysterious in cellular biology has been given a new twist. Researchers now show that prions, proteins that transmit heritable information without DNA or RNA, can contribute to ... read more
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