Huntington's Disease News

June 17, 2025

Top Headlines

Gene Editing Disrupts Huntington's Mutation in Mice

May 29, 2025 — Researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and Friedreich's ataxia. If longer than a certain threshold length, these sequences grow in length uncontrollably and lead to brain cell death in ...

Research Untangles Role of Stress Granules in Neurodegenerative Disease

May 28, 2025 — Scientists found that stabilizing stress granules suppresses the effects of ALS-causing mutations, correcting previous models that imply stress granules promote amyloid ...

Sugar-Coated Nanotherapy Dramatically Improves Neuron Survival in Alzheimer's Model

May 14, 2025 — In many neurodegenerative diseases, proteins misfold and clump together in brain tissue. Scientists developed a new therapy made of peptides and a sugar that naturally occurs in plants. The ...

Study Finds One Protein That Mitigates Huntington's Disease, and One That Exacerbates It

May 6, 2025 — Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell ...

First Synthetic 'Mini Prion' Shows How Protein Misfolding Multiplies

Apr. 30, 2025 — Prions transmit their abnormally folded shape onto other proteins. Researchers designed a synthetic fragment of the tau protein that exhibits prion-like behavior. Misfolded tau proteins are the hallmark of many neurodegenerative diseases, including ...

ATP Prevents Harmful Aggregation of Proteins Associated With Parkinson's and ALS

Apr. 23, 2025 — While a comprehensive cure-all to these neurological conditions is unlikely, scientists are making headway into understanding their fundamental characteristics with the hope of preventing or ...

The Brain Resorts to Myelin When Other Brain Nutrients Are Depleted

Apr. 13, 2025 — Marathon runners experience reversible changes in their brain myelin. These findings indicate that myelin (a substance that surrounds the neurons) exhibits behavior that was previously unknown, and that it contributes towards the brain's energy ...

ALS Drug Effectively Treats Alzheimer's Disease in New Animal Study

Apr. 8, 2025 — Experimental drug NU-9 -- a small molecule compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials for the treatment of amyotrophic lateral sclerosis (ALS) -- improves neuron health in animal models of Alzheimer's ...

Brain's Own Repair Mechanism: New Neurons May Reverse Damage in Huntington's Disease

Apr. 7, 2025 — New research shows that the adult brain can generate new neurons that integrate into key motor circuits, findings that may point to a new way to treat neurogenerative ...

Anti-Amyloid Drug Shows Signs of Preventing Alzheimer's Dementia

Mar. 20, 2025 — An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a new study. The findings suggest -- for the first time in a clinical ...

New 4D Brain Map Reveals Potential Early Warning Signs of Multiple Sclerosis

Mar. 2, 2025 — Using an animal model of multiple sclerosis (MS), researchers have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. These findings provide a ...

A Single Protein May Have Helped Shape the Emergence of Spoken Language

Feb. 18, 2025 — How much does the evolution of human speech owe to one amino ...

Latest Headlines

updated 2:05am EDT

Mystery Solved: New Study Reveals How DNA Repair Genes Play a Major Role in Huntington's Disease

Feb. 11, 2025 — A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are ...

New Drug Shows Promise in Restoring Vision for People With Nerve Damage

Jan. 27, 2025 — Researchers have found a promising drug candidate that could help restore vision in individuals with multiple sclerosis (MS) and other neurological conditions that damage ...

Researchers Map the Brain's Self-Healing Abilities After Stroke

Jan. 24, 2025 — A new study sheds light on one of the most severe consequences of stroke: damage to the brain's 'cables'-- the so-called nerve fibers -- which leads to permanent ...

Brain Changes in Huntington's Disease Decades Before Diagnosis Will Guide Future Prevention Trials

Jan. 18, 2025 — Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a ...

Study Finds Surprising Way That Genetic Mutation Causes Huntington's Disease, Transforming Understanding of the Disorder

Jan. 17, 2025 — Scientists have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of ...

Fatal Neurodegenerative Disease in Kids Also Affects the Bowel

Jan. 15, 2025 — Researchers have described the neurodegeneration that occurs in the nervous system of the bowel in Batten disease, a rare and fatal genetic condition. In their latest study, a team showed that gene ...

Human 'Domainome' Reveals Root Cause of Heritable Disease

Jan. 8, 2025 — Unstable proteins are the main drivers of many different heritable diseases, according to a new study, including genetic disorders responsible for the formation of cataracts, and different types of ...

Lasting Effects of Common Herbicide on Brain Health

Dec. 4, 2024 — New research identifies an association between glyphosate exposure in mice and symptoms of neuroinflammation, as well as accelerated Alzheimer's disease-like pathology. This study tracks both the ...

New Hope for Schizophrenia: iTBS Over the Left DLPFC Improves Negative and Cognitive Symptoms

Dec. 3, 2024 — Theta burst stimulation (TBS) is a non-invasive brain stimulation technique known for modifying human behavior and treating neurological diseases. A ...

Trial Shows Alcohol-Mimicking Medication Can Give Laryngeal Dystonia Patients Back Their Voice

Nov. 20, 2024 — Researchers have led a clinical trial of a drug that mimics the effects of alcohol in more than 100 patients with laryngeal dystonia, a neurological ...

Study Explores Whether CBD Can Reduce Scan-Related Anxiety in Patients With Advanced Breast Cancer

Dec. 16, 2024 — A new study explores whether cannabidiol (CBD), a component of marijuana, can reduce anxiety levels, specifically among patients with advanced breast cancer before a scan assessing tumor ...

Huntington's Disease Gene Also Enhances Early Brain Development and Intelligence, Study Finds

Nov. 13, 2024 — The Huntington's disease (HD) mutation eventually causes a fatal brain disease in adulthood, but a new study finds that early in life, children with the HD mutation have bigger brains and higher ...

Mice Tails Whip Up New Insights Into Balance and Neurodegenerative Disease Research

Nov. 6, 2024 — Why do mice have tails? The answer to this is not as simple as you might think. Research has shown that there's more to the humble mouse tail than previously assumed. Using a novel experimental ...

Researchers Solve Medical Mystery of Neurological Symptoms in Kids

Oct. 31, 2024 — A team of doctors and scientists have identified the cause of a rare disorder involving intellectual disability and brain malformations. The team found a link between the child's neurological ...

Discovery of Key Mechanism in Huntington's Disease Could Pave the Way for Early Detection and Treatment

Oct. 29, 2024 — Researchers have identified a key biochemical mechanism relevant to the development of Huntington's Disease. This discovery opens up the possibility of studying the disease before its clinical ...

Gene Named for Mythical Irish Land Could Aid Muscle Function After Traumatic Nerve Injuries

Oct. 25, 2024 — Researchers describe how a gene called NANOG can improve the regrowth of damaged nerves after traumatic nerve injuries, like those sustained in motor vehicle accidents or gunshot ...

Could a New Medical Approach Fix Faulty Genes Before Birth?

Oct. 24, 2024 — A new biomedical tool successfully delivers genetic material to edit faulty genes in developing fetal mouse brain cells. This might stop disease progression of genetic-based neurodevelopmental ...

Ancient Viral DNA in the Human Genome Linked to Multiple Sclerosis and Amyotrophic Lateral Sclerosis

Oct. 21, 2024 — New research has revealed a connection between ancient viral DNA embedded in the human genome and the genetic risk for two major diseases that affect the central nervous ...

Researchers Discover What Hinders DNA Repair in Patients With Huntington's Disease

Sep. 27, 2024 — Researchers have made an important Huntington's disease discovery. They have found that the protein mutated in patients with Huntington's disease doesn't repair DNA as intended, ...

Bringing Lost Proteins Back Home

Sep. 22, 2024 — A new method for relocating proteins that have been misplaced in cells could mean new treatments for cancers and ...

New Therapy That Targets and Destroys Tau Tangles Is a Promising Future Alzheimer's Disease Treatment

Sep. 16, 2024 — Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer's disease, and improve symptoms of neurodegeneration in ...

Novel Immunotherapy Improves Recovery from Spinal Cord Injury

Sep. 4, 2024 — Researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from ...

A New Culprit in Huntington's Disease

Aug. 22, 2024 — Researchers have implicated a new gene in the progression of Huntington's disease in a brain organoid model. The gene may contribute to brain abnormalities much earlier than previously ...

Taming Parkinson's Disease With Intelligent Brain Pacemakers

Aug. 19, 2024 — Two new studies are pointing the way toward round-the-clock personalized care for people with Parkinson's disease through an implanted device that can treat movement problems during the day and ...

Rewriting the Evolutionary History of Critical Components of the Nervous System

Aug. 13, 2024 — A new study has rewritten the conventionally understood evolutionary history of certain ion channels -- proteins critical for electrical signaling in the nervous system. The study shows that the ...

Study Reveals Ways in Which 40Hz Sensory Stimulation May Preserve Brain's 'White Matter'

Aug. 9, 2024 — Scientists report that gamma frequency light and sound stimulation preserves myelination in mouse models and reveal molecular mechanisms that may underlie the ...

Could This New Drug Turn Back the Clock on Multiple Sclerosis?

Aug. 5, 2024 — Multiple sclerosis (MS) degrades the protective insulation around nerve cells, leaving their axons, which carry electrical impulses, exposed like bare wires. This can cause devastating problems with ...

Building Bridges Between Cells for Brain Health

July 26, 2024 — The brain contains many cell types, from the prominent neurons to the lesser-known microglia. The latter are integral to the brain's immune system and play a crucial role as the brain's ...

Brain Fluid Dynamics Key to Migraine Mysteries, New Therapies

July 4, 2024 — New research details the connection between the neurological symptoms associated with aura and the migraine that follows. The study also identifies new proteins that could be responsible for ...

Cracking the Code for Cerebellar Movement Disorders

July 3, 2024 — A recent study found that the way cerebellar neurons communicate with other brain regions is different in various movement ...