Mice News

June 13, 2025

Top Headlines

Synthetic Compound Shows Promise Against Multidrug Resistance

June 2, 2025 — Researchers have synthesized a new compound called infuzide that shows activity against resistant strains of ...

Newly Identified Group of Nerve Cells in the Brain Regulates Bodyweight

May 28, 2025 — Obesity is a global health problem that affects many people. In recent years, very promising anti-obesity drugs have been developed. Despite these successes, there are patients who do not respond to these drugs or suffer from side effects. ...

Yeast Can Now Produce Human DNase1

May 28, 2025 — The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis. However, it takes considerable effort to produce it in immortalized hamster ...

A High-Fat Diet Sets Off Metabolic Dysfunction in Cells, Leading to Weight Gain

May 28, 2025 — Researchers find high-fat diets set off metabolic dysfunction in cells, leading to weight gain, but these effects can be reversed by treatment with an ...

Intestinal Bacteria Influence Aging of Blood Vessels

May 28, 2025 — The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers have now shown for the first time that intestinal bacteria and their metabolites contribute directly to vascular aging. As people age, the bacterial ...

The Dietary Bug in a Cancer Therapy

May 21, 2025 — A study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer ...

Researchers Identify a Dual Origin of Cells Controlling Puberty and Reproduction

May 21, 2025 — Researchers have shown that gonadotrophs, cells in the pituitary gland with a key role in puberty and reproduction, come from two different populations, with the majority produced after birth rather ...

Gut Bacteria and Acetate, a Great Combination for Weight Loss

May 19, 2025 — Researchers have discovered a new way to reduce obesity. Supplying the gut with extra acetate reduces fat and liver mass in both normal and obese mice, as long as bacteria of the Bacteroides species is also present. When both these conditions are ...

Fast Food, Fast Impact: How Fatty Meals Rapidly Weaken Our Gut Defenses

May 19, 2025 — A study has become the first in the world to unravel the immediate effects of a high-fat diet on our gut ...

Mice Use Chemical Cues Such as Odors to Sense Social Hierarchy

May 19, 2025 — Researchers have shown that mice use chemical cues, including odors, to detect the social rank of an unfamiliar mouse and compare it to their own, using this information to determine their ...

Overlooked Cell Type Orchestrates Brain Rewiring

May 16, 2025 — Researchers have shown in mice that brain cells known as astrocytes are required for a signaling chemical called norepinephrine to modify brain activity, changing the textbook understanding that norepinephrine acts directly on ...

Improved Model System Allows Researchers to Study Embryo Development

May 15, 2025 — Research improves upon a popular experimental model of mammal development and in doing so, reveals more of the inner workings of a critical period during the formation of an ...

Latest Headlines

updated 1:01pm EDT

Key Player in Childhood Food Allergies Identified: Thetis Cells

May 15, 2025 — Thetis cells, a class of immune cells first described in 2022, play an essential and previously unknown role in suppressing inflammatory responses to food, a new study ...

Making Connections: A Three-Dimensional Visualization of Musculoskeletal Development

May 14, 2025 — Using a new fluorescent mouse model with advanced imaging techniques, researchers have successfully visualized how musculoskeletal components are ...

Heart Rhythm Disorder Traced to Bacterium Lurking in Our Gums

May 9, 2025 — New research shows that the gum disease bacterium P. gingivalis can slip into the bloodstream and infiltrate the heart. There, it quietly drives scar tissue buildup -- distorting the heart's ...

Novel, Needle-Free, Live-Attenuated Influenza Vaccines With Broad Protection Against Human and Avian Virus Subtypes

May 9, 2025 — A research team has achieved a significant breakthrough in developing broadly protective, live-attenuated influenza vaccines (LAIV). These innovative ...

Mammal's Lifespans Linked to Brain Size and Immune System Function, Says New Study

May 8, 2025 — Why do cats generally live longer than dogs? New research suggests that longer lifespans of mammals like cats could be linked to their bigger brains ...

Evaluating the Safety and Efficacy of a Smallpox Vaccine for Preventing Mpox

May 8, 2025 — The recent global monkeypox (mpox) outbreak, with a new and aggressive variant, has underscored the dire need for safe, broadly effective, and ...

Engineering an Antibody Against Flu With Sticky Staying Power

May 8, 2025 — Scientists have engineered a monoclonal antibody that can protect mice from a lethal dose of influenza A, a new study shows. The new molecule combines the specificity of a mature flu fighter with the ...

AI-Designed DNA Controls Genes in Healthy Mammalian Cells for First Time

May 8, 2025 — A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

Klotho: A Protein That Promotes Healthy Aging and Improves Longevity

May 7, 2025 — An international study has shown that increasing levels of the Klotho protein in mice extends lifespan and improves both physical and cognitive health when ...

Food as Medicine: How Diet Shapes Gut Microbiome Health

May 6, 2025 — Researchers show how mice fed a Western-style diet are not able to rebuild a 'healthy,' diverse gut microbiome following antibiotic treatment. These mice were also more susceptible to infection by ...

Researchers Restore Antibiotic Effect in the Event of Resistance

May 7, 2025 — Bacterial resistance negates the effect of antibiotics in the treatment of infection. Using mouse models, researchers now show that if antibiotics are administered with an enzyme called endolysin, ...

Genomic Survey Uncovers Evolutionary Origins of Secretoglobins

May 5, 2025 — At a conference in Washington D.C. in 2000, the secretoglobin super family of proteins was named to classify proteins with structural similarities to its founding member uteroglobin. Now, 25 years ...

Antivenom Neutralizes the Neurotoxins of 19 of the World's Deadliest Snakes

May 2, 2025 — By using antibodies from a human donor with a self-induced hyper-immunity to snake venom, scientists have developed the most broadly effective antivenom to date, which is protective against the likes ...

A Digestive 'Treasure Chest' Shows Promise for Targeted Drug Treatment in the Gut

May 1, 2025 — A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments. The proof-of-concept study introduced a ...

Designer Microbe Shows Promise for Reducing Mercury Absorption from Seafood

May 1, 2025 — Scientists inserted DNA-encoding methylmercury detoxification enzymes into the genome of an abundant human gut bacterium. The engineered bacterium detoxified methylmercury in the gut of mice and ...

Once Bitten, Animals Develop Resistance That Shrinks Tick Population

Apr. 30, 2025 — Just in time for tick season, new research is shining a light on how animals develop resistance to tick bites, which points toward the possibility of developing more effective vaccines against the ...

New Technology Facilitates Delivery of Advanced Medicines

Apr. 30, 2025 — Researchers have developed a technique that enables efficient delivery of therapeutic proteins and RNA to cells. The method shows promising results in animal studies to deliver gene editors and ...

Protein Sources Change the Gut Microbiome -- Some Drastically

Apr. 30, 2025 — Protein sources appear to have major effects on both the population and function of the mouse gut ...

New Mouse Brain Atlas Will Accelerate Studies of Neurological Disorders

Apr. 30, 2025 — A new 3D 'atlas' of the mouse brain promises to sharpen scientists' ability to measure brain changes and share findings across studies of diseases like Alzheimer's. The mouse ...

Viewing Organs in 3D

Apr. 28, 2025 — It is now possible to obtain three-dimensional, high-resolution images of enzyme activity in tissue samples or whole organs -- thanks to probe molecules that anchor fluorescent dyes within tissue as ...

Bacteria's Mysterious Viruses Can Fan Flames of Antibiotic Damage

Apr. 28, 2025 — Scientists built a model that allows them to diminish phage communities from a mouse gut microbiome -- and then bring them back -- without affecting the bacteria. On a test run of their model, ...

Blocking a Surprising Master Regulator of Immunity Eradicates Liver Tumors in Mice

Apr. 24, 2025 — 'Cold' tumors are resistant to common immunotherapies. Researchers have uncovered a master regulator that can be manipulated to prevent tumor growth in ...

One Gene Defines the Many Patterns of Snake Skin

Apr. 24, 2025 — In many animals, skin coloration and its patterns play a crucial role in camouflage, communication, or thermoregulation. In the corn snake, some morphs display red, yellow, or pink blotches, and ...

How Bacteria in Our Aging Guts Can Elevate Risk of Leukemia and Perhaps More

Apr. 23, 2025 — Scientists have discovered a surprising new connection between gut health and blood cancer risk one that could transform how we think about aging, inflammation, and the early stages of ...

Researchers Use Machine Learning to Engineer 'Bespoke Enzymes' for Gene Editing

Apr. 22, 2025 — Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein ...

Obesity Disrupts 'Reaction Time' to Starvation in Mice

Apr. 22, 2025 — Researchers have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network. This is a ...

Experimental Cancer Drug Could Streamline Standard Tuberculosis Treatment and Prevent Post-TB Lung Disease, Study Suggests

Apr. 21, 2025 — An experimental drug now in clinical trials as a cancer treatment could help boost the power of first-line tuberculosis (TB) treatments by helping infected cells die a gentler death, investigators ...

Engineered Microglia Show Promise for Treating Alzheimer's and Other Brain Diseases

Apr. 21, 2025 — A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease and other neurological disorders, according to scientists. By engineering ...

Immune System Proteins Involved in Severe Parasitic Disease Identified

Apr. 21, 2025 — New insights into the mechanisms that cause more severe cases of schistosomiasis -- a disease caused by parasitic worms and second only to malaria in terms of potential harm -- have been ...

Experimental Bird Flu Vaccine Excels in Animal Models

Apr. 17, 2025 — A vaccine under development has demonstrated complete protection in mice against a deadly variant of the virus that causes bird flu. The work focuses on the H5N1 variant known as 2.3.4.4b, which has ...