Crohn's Disease News

April 25, 2024

Top Headlines

Scientists Discover the Cellular Functions of a Family of Proteins Integral to Inflammatory Diseases

Apr. 22, 2024 — In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to ...

Hope for Treating Autoimmune Diseases

Apr. 3, 2024 — A routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) uses information from routine laboratory ...

Implantable Sensor Could Lead to Timelier Crohn's Treatment

Mar. 18, 2024 — Scientists have developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent ...

Treating Newly-Diagnosed Crohn's Patients With Advanced Therapy Leads to Dramatic Improvements in Outcomes

Feb. 22, 2024 — A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, ...

Latest Headlines

updated 3:14pm EDT

Apply Single-Cell Analysis to Reveal Mechanisms of a Common Complication of Crohn's Disease

Apr. 24, 2024 — Study identifies key pathways underlying perianal fistula, a disease complication that is more prevalent and severe in African American ...

New Inflammatory Bowel Disease Testing Protocol Could Speed Up Diagnosis

Apr. 16, 2024 — Patients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study ...

Gene Analysis Generates Spatial Map of Intestinal Cells and Traces Their Trajectories During Gut Inflammation

Apr. 2, 2024 — Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis. Certain chronic disorders are ...

New Understanding of the Gut Immune System May Hold Promise for Crohn's Disease Patients

Mar. 13, 2024 — Scientists uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease. The discovery may ...

Mood Interventions May Reduce Inflammation in Crohn's and Colitis

Jan. 24, 2024 — New research reveals that interventions which improve mood can reduce levels of inflammation in people with inflammatory bowel disease by 18 per cent, compared to having no mood ...

Researchers Reveal Prevalence of Persistent Symptoms in Patients With Microscopic Colitis

Dec. 13, 2023 — A new study examines how multiple factors contribute to the miscommunication and understanding of the digestive disease, microscopic ...

Comprehensive Guideline on Using Biomarkers for Monitoring Crohn's Disease

Nov. 17, 2023 — New AGA guideline outlines reliable blood and stool tests to monitor inflammation that can reduce how often patients need invasive ...

Early Life Exposure to Broccoli Sprouts Protects Against Colitis in Inflammatory Bowel Disease

Nov. 9, 2023 — High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life ...

Body Changes Up to Eight Years Before Inflammatory Bowel Disease Diagnosis

Nov. 7, 2023 — Researchers have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn's disease and up to three years before a diagnosis of ulcerative ...

Risk of Serious Infection Even in Low-Active IBD

Nov. 1, 2023 — Inflammatory bowel disease (IBD) is an independent risk factor for serious infection, even at very low levels of gastrointestinal ...

A Promising Target to Fight Inflammatory Bowel Diseases

Oct. 26, 2023 — Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, arise when there is a dysregulation of cell signalling pathways, leading to a chronic inflammatory response. ...

Fungi Used in Food Production Could Lead to New Probiotics

Oct. 26, 2023 — According to a new study, 2 fungi used to produce food products have potential probiotic effects on gut ...

Inflammatory Bowel Disease Linked to Atopic Dermatitis

Sep. 19, 2023 — Adults with atopic dermatitis (AD) have a 34 percent increased risk of developing new-onset inflammatory bowel disease (IBD) compared with individuals who do not have the skin condition, and children ...

Developing a Less Invasive Test for Inflammatory Bowel Disease

Sep. 7, 2023 — Millions of Americans have inflammatory bowel disease (IBD), which occurs in one of two forms: Crohn's disease or ulcerative colitis. Though the two have similar symptoms, they require different ...

Neonatal Stem Cells from the Heart Could Treat Crohn's Disease

July 28, 2023 — Research found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse ...

Nanomedicine for Treating Inflammatory Bowel Disease

July 17, 2023 — Chronic inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects. A ...

Scientists Link Genes to Diet in Inflammatory Bowel Disease

July 5, 2023 — A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in ...

Pathogenic Bacteria Use a Sugar in the Intestinal Mucus Layer to Infect the Gut, Study Shows

July 3, 2023 — A new study shows the sugar sialic acid, which makes up part of the protective intestinal mucus layer, fuels disease-causing bacteria in the gut. The findings suggest a potential treatment target for ...

Helping 'Good' Gut Bacteria and Clearing out the 'Bad' -- All in One Treatment

June 21, 2023 — Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective ...

New Research Identifies Cells Linking Chronic Psychological Stress to Inflammatory Bowel Disease

June 8, 2023 — For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, ...

Study Gives Insight Into Cause of Severe Inflammatory Bowel Disease

Apr. 20, 2023 — Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant ...

Study Sheds Light on How IBD Can Develop

Apr. 7, 2023 — A new study could help improve personalized medicine approaches in inflammatory bowel disease by understanding how patients with variants in the PTPN2 gene develop ...

Study to Decode Microbe-Gut Signaling Suggests Potential New Treatment for IBD

Apr. 4, 2023 — Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's ...

Engineered E. Coli Delivers Therapeutic Nanobodies to the Gut

Mar. 31, 2023 — Researchers have succeeded in developing an E. coli-based 'smart microbe' that secretes therapeutic payloads, including antibodies, into the gut. The genetically modified beneficial strain ...

Digital Twin Opens Way to Effective Treatment of Inflammatory Diseases

Feb. 28, 2023 — Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. This means that currently available drugs have little ...

Psyllium Fiber Protects Against Colitis by Activating Bile Acid Sensor, Biomedical Sciences Researchers Find

Feb. 23, 2023 — Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new ...

Compound Reverses Gut Inflammation in Mice

Dec. 12, 2022 — A new drug acts like a master reset switch in the intestines. The compound, called FexD, has previously been found to lower cholesterol, burn fat, and ward off colorectal cancer in mice. Now, the ...

Rheumatoid Arthritis Drugs Lower Risk of Heart Disease, Study Shows

Dec. 8, 2022 — Commonly used drugs that reduce joint inflammation in patients with rheumatoid arthritis also reduce vascular inflammation and cardiovascular risk, finds a new ...

Common Immune Cells Can Prevent Intestinal Healing

Dec. 2, 2022 — B cells are critical to the proper functioning of the immune system. However, researchers have shown that they can sometimes do more harm than good, as their numbers greatly increase after bowel ...

To Trigger Crohn's Disease, Pathogenic Bacteria Co-Opt a Genetic Susceptibility

Dec. 1, 2022 — Changes in a single gene open the door for harmful gut bacteria to set off the inflammation that drives Crohn's disease, according to a new study. These findings could one day help doctors ...